Prakriya Lab
Selected publications:
Novakovic MM, Korshunov KS, Grant RA, Martin ME, Valencia HA, Budinger GRS, Radulovic J, and Prakriya M (2023) Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels. Nature Communications. 14:5500. doi:10.1038/s41467-023-40968-6.
Tsujikawa S, Demeulenaere KE, Centeno MV, Ghazisaeidi S, Martin ME, Tapies MR, Maneshi MM, Yamashita M, Stauderman KA, Apkarian AV, Salter MW, and Prakriya M (2023). Regulation of neuropathic pain by microglial Orai1 channels. Science Advances. doi/10.1126/sciadv.ade7002.
Yeung S-W P, Yamashita M, and Prakriya M (2023). A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels. eLife. doi.org/10.7554/eLife.82281.
Kountz TS, Biyasheva A, Schleimer RP, and Prakriya M (2022). Extracellular Nucleotides and Histamine Suppress TLR3- and RIG-I-Mediated Release of Antiviral IFNs from Human Airway Epithelial Cells. J Immunology 208(10):2390-2402.
Kountz TS, Jairaman A, Kountz CD, Stauderman KA, Schleimer RP, and Prakriya M (2021). Differential regulation of ATP-evoked PGE2 and IL-6 synthesis by human airway epithelial cells. J Immunology 207(5):1275-1287.
Maneshi MM, Toth AB, Ishii T, Hori K, Tsujikawa S, Shum AK, Shrestha N, Yamashita M, Miller RJ, Radulovic J, Swanson GT, and Prakriya M (2020). Orai1 channels are essential for amplification of glutamate-evoked Ca2+ signals in dendritic spines to regulate working and associative memory. Cell Reports. 33:108464. doi: 10.1016/j.celrep.2020.108464.
Yeung S-W P, Ing CE, Yamashita M, Pomès R, and Prakriya M (2020). A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore. eLife. DOI: 10.7554/eLife.60751.
Toth AB, Hori K, Novakovic, MM, Bernstein NG, Lambot L, and Prakriya M (2019), CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission. Science Signaling 12, eaaw5450. (cover article).
Yeung P S-W, Yamashita M, Ing CE, Pomes R, Freymann D, and Prakriya M (2018). Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating. Proc. Natl. Acad. Sci. USA. 15:E5193-E5202. doi: 10.1073/pnas.1718373115.
Yamashita M, Yeung P S-W, Ing CE, McNally BA, Pomes R, Prakriya M (2017). STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate. Nature Communications. 8, 14512, DOI 10:1038/ncomms14512.
Prakriya M, Lewis RS (2015). Store operated calcium channels. Physiological Reviews. 95: 1383-1436.
Jairaman A, Yamashita M, Schleimer RP, Prakriya M (2015). Store-operated CRAC channels regulate PAR2-activated Ca2+ signals and cytokine production in airway epithelial cells. Journal of Immunology. 195: 2122-2133.
