Northwestern University Feinberg School of Medicine

Opal Laboratory



View the Opal Laboratory's publications in PubMed


Mutant ataxin-1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018 June 1;128(6):2252-2265. Edamakanti CR, Do J, Didonna A, Martina M, Opal P. PMID: 29533923


Mutant ataxin-1 inhibits neural progenitor cell proliferation in SCA1. Cerebellum. 2017 Apr;16(2):340-347. Cvetanovic M, Hu YS, Opal P. PMID: 27306906


The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP. Mol Biol Cell. 2016 Dec 15;27(25):3980-3990. Lin NH, Huang YS, Opal P, Goldman RD, Messing A, Perng MD. PMID: 27798231

Advances in sequencing technologies for understanding hereditary ataxias: a review. JAMA Neurol. 2016 Dec 1;73(12):1485-1490. Didonna A, Opal P. PMID: 27749953

Paraneoplastic cerebellar degeneration with anti-Yo antibodies - a review. Ann Clin Transl Neurol. 2016 Jun 30;3(8):655-63. Venkatraman A, Opal P. PMID: 27606347

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy. Hum Mol Genet. 2016 Jun 1;25(11):2143-2157. Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P. PMID: 27000625


Neuronal atrophy early in degenerative ataxia is a compensatory mechanism to regulate membrane excitability. J Neurosci. 2015 Aug 12;35(32):11292-307. Dell'Orco JM, Wasserman AH, Chopra R, Ingram MA, Hu YS, Singh V, Wulff H, Opal P, Orr HT, Shakkottai VG. PMID: 26269637

The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurosci. 2015 Jan;2(1):79-101. Didonna A, Opal P. PMID: 25642438


Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.Neuroscience. Epub January 2015Cvetanovic M., Ingram M., Orr, H., and Opal P. PMID: 25595967

An investigation of diffusion imaging techniques in the evaluation of spinocerebellar ataxia and multisystem atrophyJ Clin Neurosci. 2015 Jan;22(1):166-72. doi: 10.1016/j.jocn.2014.08.006. Epub 2014 Nov 26. Rozenfeld MN, Nemeth AJ, Walker MT, Mohan P, Wang X, Parrish TB, Opal P. PMID: 25439745

The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15;23(14):3733-45. Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. PMID: 24594842


Explaining intermediate filament accumulation in giant axonal neuropathyRare Dis. 2013 Jun 17;1:e25378. Opal P, Goldman RD. PMID: 25003002

Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May 1;123(5):1964-75. Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. PMID: 23585478


LANP mediates neuritic pathology in Spinocerebellar ataxia type 1. Neurobiol Dis. 2012 Dec;48(3):526-32. Cvetanovic M, Kular RK, Opal P. PMID: 22884877


Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1. Nat Med. 2011 Oct 16;17(11):1445-7. Cvetanovic M, Patel JM, Marti HH, Kini AR, Opal P. PMID: 22001907


Cpd-1 null mice display a subtle neurological phenotype. PLoS One. 2010 Sep 9;5(9). pii: e12649. Kular RK, Gogliotti RG, Opal P. PMID: 20844742


Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex. J Biol Chem. 2009 Mar 20;284(12):7783-92. Kular RK, Cvetanovic M, Siferd S, Kini AR, Opal P. PMID: 19136565


Association of spinocerebellar ataxia type 3 and spinocerebellar ataxia type 8 microsatellite expansions: genetic counseling implications. Mov Disord. 2008 Jan;23(1):154-5. Paganoni S, Seelaus CA, Ormond KE, Opal P. PMID: 17987652


The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. EMBO Rep. 2007 Jul;8(7):671-7. Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P. PMC: 1905893

Huntington's disease presenting as postsurgical psychosis. Mov Disord. 2007 Jun 15;22(8):1209-10. Paganoni S, Naidech AM, Opal P. PMID: 17443707