In the Kosak lab, we investigate the relationship between nuclear and genomic organization with that of nuclear processes. One classic example of this relationship is the localization of gene loci within the nucleus relative to gene expression: with silenced genes frequently positioned at heterochromatin and the nuclear periphery, and active genes enriched in the nuclear interior.  We have established a relationship between gene expression and genomic organization during cellular differentiation by contrasting the linear arrangement of co-regulated genes and the organization of all chromosomes in various cell types. We postulate that the inter-linked functions of the nucleus results in its self-organization, defined as the emergence of a global structure from combined local activities, and that disruption of this organization contributes to nuclear dysfunction and disease.

© STeven Kosak 2017