Northwestern University Feinberg School of Medicine

Evangelos Kiskinis Lab

About Our Lab

Our research program is focused on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of disease. We have two clinical interests, motor neuron disease and epileptic channelopathies. We utilize patient-specific induced pluripotent stem cells (iPSCs) and direct reprogramming methods to generate different neuronal subtypes implicated in these diseases. We then study these cells by a combination of genomic approaches and functional physiological assays. Our hope is that these disease model systems will help us identify points of effective and targeted therapeutic intervention. Find news and more information about our lab.

Selected Publications

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology.Cell Stem Cell. 2018 Apr 5;22(4):559-574 Ziller MJ, Ortega JA, Quinlan KA, Santos DP, Gu H, Martin EJ, Galonska C, Pop R, Maidl S, Di Pardo A, Huang M, Meltzer HY, Gnirke A, Heckman CJ, Meissner A, Kiskinis E. PMID: 29551301

Pathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1.Cell Stem Cell, 2014 Jun 5;14(6):781-95. Kiskinis E*, Sandoe J*, Boulting G, Williams LA, Wainger BJ, Mikkilineni S, Merkle F, Han S, Peng T, Ziller M, Oakley DH, Ichida J, Dicostanza S, Atwater N, Maeder ML, Goodwin MJ, Joung K, Woolf CJ, Brown RH, Eggan K. PMID: 24704492

Evangelos Kiskinis, PhD

Evangelos Kiskinis, PhD
Assistant Professor in Neurology—Ken and Ruth Davee Department and Physiology

For more information, click here to visit our department page.

For ALS Patients

Clinical Trials
The Northeast ALS Consortium (NEALS) is an independent consortium of researchers who conduct clinical research in motor neuron diseases. Find information on clinical trials for ALS

ALS Clinic
The Lois Insolia ALS Clinic at the Les Turner ALS Center is dedicated to the total care and support of people with ALS, their families and caregivers.