Northwestern University Feinberg School of Medicine

James Laboratory

About Our Lab

The research activities of my laboratory are directed towards elucidating the molecular and biological consequences of specific gene alterations in CNS cancer, with particular emphasis on malignant glioma, the most common type of primary CNS tumor, and towards identifying actionable/druggable molecular characteristics of these tumors.


C. David James, PhD is part of a collaborative research team that has found a molecule that stops the growth of an aggressive pediatric brain tumor. Their findings are featured in the Northwestern Medicine News, and Nature Medicine has an advanced online publication of their research.

Amanda Saratsis, MD, Rintaro Hashizume, MD/PhD, and C. David James, PhD, and others are featured as part of an interdisciplinary team of physicians and researchers combating pediatric brain tumors in Lurie’s Heroes Spring 2016 issue

C. David James, PhD, part of multi-institutional team that explores the signaling network of glioblastoma cells and seeks new ways for treating glioblastoma

The molecular, cellular, and biological research work of C. David James, PhD is profiled in the March issue of ‘Breakthroughs’

C. David James, PhD awarded R01 grant for ‘Radiation + Temozolomide Induced Mutation and Malignant Progression of Glioblastoma’

Rintaro Hashizume, MD/PhD, Amanda Saratsis, MD, and C. David James, PhD part of pediatric brain tumor ‘Dream Team’

C. David James, PhD appointed Associate Editor of ‘Science Advances’, the recently launched journal from the American Association for the Advancement of Science. ‘Science Advances’ is the first and only open access journal of the AAAS.

Department of Neurological Surgery faculty Amanda Saratsis, MD, Rintaro Hashizume, MD/PhD, and C. David James, PhD awarded large gift from the John McNicholas Pediatric Brain Tumor Foundation

Northwestern Brain Tumor Institute Special Guest Lecture: Duane Mitchell, MD/PhD, "Cellular Immunotherapy Targeting Pediatric and Adult Brain Tumors" – Friday, October 24, 2014

Dr. James is invited to lecture at the Josephine Ford Cancer Institute Translational Research Symposium, Henry Ford Hospital, Detroit, MI, December, 2014

    Selected Publications

    Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q, Takahashi YH, Woodfin AR, Misharin AV, Abshiru NA, Lulla RR, Saratsis AM2, Kelleher NL, James CD, Shilatifard A. Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas. Nat Med. 2017 Feb 27. doi: 10.1038/nm.4296. [Epub ahead of print]

    Nathanson DA, Gini B, Mottahedeh J, Visnyeis K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao N, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, and Mischel PS. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNAScience. 343:72-6, 2014. PubMed PMID: 24310612

    Mueller S, Hashizume R, Yang X, Kolkowitz I, Olow AK, Phillips J, Smirnov I, Tom MW, Prados MD, James CD, Berger MS, Gupta N, and Haas-Kogan DA. Targeting Wee1 for the treatment of pediatric high-grade gliomasNeuro-Oncology. 16: 352-360, 2014. PubMed PMID: 24305702

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    C. David James, PhD

    C. David James, PhD

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