Welcome to the Gottfried Laboratory

Our research focuses on understanding how the human brain transforms odor inputs into olfactory percepts (such as the smell of mint, banana, or wet dog), and how learning, memory, and experience modulate odor perception at the neural and behavioral levels. To address these questions we use a combination of techniques including high-resolution olfactory functional magnetic resonance imaging (fMRI), multivariate statistical analyses, psychophysical paradigms, and physiological recordings.

More recently we have begun using intracranial EEG (iEEG) techniques in patients with medically resistant epilepsy to elucidate the spatiotemporal dynamics of odor processing in the human olfactory bulb, piriform cortex, amygdala, hippocampus, and orbitofrontal cortex. These studies will combine iEEG recordings, olfactory psychophysical paradigms, and signal processing analyses to relate cognitive and perceptual states with rhythmic activity patterns in the human brain. Insights gained from this work will represent an important step forward in clarifying the neurobiology of the human olfactory system.