Northwestern University Feinberg School of Medicine

Cara Gottardi Lab

Publications

Learn more about the work that we do in the Gottardi Laboratory through our recent publications.

  1. Chiarella SE, Rabin EE, Ostilla LA, Flozak AS, Gottardi CJ  αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family.  Tissue Barriers  2018 May 10;:e1463896. doi:10.1080/21688370.2018.1463896
  2. Wood MN, Ishiyama N, Singaram I, Chung CM, Flozak AS, Yemelyanov A, Ikura M, Cho W, Gottardi CJ  α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion.  J Cell Biol  2017 11 06;216(11):3767-3783. doi:10.1083/jcb.201612006
  3. Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H  Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.  J Exp Med  2017 Aug 07;214(8):2387-2404. doi:10.1084/jem.20162152
  4. Loffredo LF, Abdala-Valencia H, Anekalla KR, Cuervo-Pardo L, Gottardi CJ, Berdnikovs S  Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma.  Allergy  2017 Dec;72(12):1988-2004. doi:10.1111/all.13222
  5. Folmsbee SS, Gottardi CJ  Cardiomyocytes of the Heart and Pulmonary Veins: Novel Contributors to Asthma?  Am J Respir Cell Mol Biol  2017 11;57(5):512-518. doi:10.1165/rcmb.2016-0261TR
  6. Serebryannyy LA, Yemelyanov A, Gottardi CJ, de Lanerolle P  Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin.  J Cell Sci  2017 May 15;130(10):1717-1729. doi:10.1242/jcs.199893
  7. Sennello JA, Misharin AV, Flozak AS, Berdnikovs S, Cheresh P, Varga J, Kamp DW, Budinger GR, Gottardi CJ, Lam AP  Lrp5/β-Catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis.  Am J Respir Cell Mol Biol  2017 Feb;56(2):191-201. doi:10.1165/rcmb.2016-0147OC
  8. Flozak AS, Lam AP, Gottardi CJ  A Simple Method to Assess Abundance of the β-Catenin Signaling Pool in Cells.  Methods Mol Biol  2016;1481:49-60. doi:10.1007/978-1-4939-6393-5_6
  9. Serebryannyy LA, Parilla M, Annibale P, Cruz CM, Laster K, Gratton E, Kudryashov D, Kosak ST, Gottardi CJ, de Lanerolle P  Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.  J Cell Sci  2016 09 15;129(18):3412-25. doi:10.1242/jcs.195867
  10. Folmsbee SS, Wilcox DR, Tyberghein K, De Bleser P, Tourtellotte WG, van Hengel J, van Roy F, Gottardi CJ  αT-catenin in restricted brain cell types and its potential connection to autism.  J Mol Psychiatry  2016;4:2. doi:10.1186/s40303-016-0017-9
  11. Folmsbee SS, Budinger GR, Bryce PJ, Gottardi CJ  The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation.  J Allergy Clin Immunol  2016 07;138(1):123-129.e2. doi:10.1016/j.jaci.2015.11.037
  12. Chen Y, Li Y, Xue J, Gong A, Yu G, Zhou A, Lin K, Zhang S, Zhang N, Gottardi CJ, Huang S  Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.  EMBO J  2016 Mar 15;35(6):668-84. doi:10.15252/embj.201592810
  13. Reinke L, Lam AP, Flozak AS, Varga J, Gottardi CJ  Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling.  Biochem Biophys Res Commun  2016 Feb 12;470(3):606-612. pii:S0006-291X(16)30097-3
  14. McCrea PD, Gottardi CJ  Beyond β-catenin: prospects for a larger catenin network in the nucleus.  Nat Rev Mol Cell Biol  2016 Jan;17(1):55-64. doi:10.1038/nrm.2015.3
  15. Li J, Newhall J, Ishiyama N, Gottardi C, Ikura M, Leckband DE, Tajkhorshid E  Structural Determinants of the Mechanical Stability of α-Catenin.  J Biol Chem  2015 Jul 31;290(31):18890-903. doi:10.1074/jbc.M115.647941
  16. McCrea PD, Maher MT, Gottardi CJ  Nuclear signaling from cadherin adhesion complexes.  Curr Top Dev Biol  2015;112:129-96. doi:10.1016/bs.ctdb.2014.11.018
  17. Escobar DJ, Desai R, Ishiyama N, Folmsbee SS, Novak MN, Flozak AS, Daugherty RL, Mo R, Nanavati D, Sarpal R, Leckband D, Ikura M, Tepass U, Gottardi CJ  α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.  J Cell Sci  2015 Mar 15;128(6):1150-65. doi:10.1242/jcs.163824
  18. Folmsbee SS, Morales-Nebreda L, Van Hengel J, Tyberghein K, Van Roy F, Budinger GR, Bryce PJ, Gottardi CJ  The cardiac protein αT-catenin contributes to chemical-induced asthma.  Am J Physiol Lung Cell Mol Physiol  2015 Feb 01;308(3):L253-8. doi:10.1152/ajplung.00331.2014
  19. Valenti F, Ibetti J, Komiya Y, Baxter M, Lucchese AM, Derstine L, Covaciu C, Rizzo V, Vento R, Russo G, Macaluso M, Cotelli F, Castiglia D, Gottardi CJ, Habas R, Giordano A, Bellipanni G  The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.  J Cell Biochem  2015 Mar;116(3):418-30. doi:10.1002/jcb.24993
  20. McEwen AE, Maher MT, Mo R, Gottardi CJ  E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion.  Mol Biol Cell  2014 Aug 15;25(16):2365-74. doi:10.1091/mbc.E14-01-0690
  21. Lam AP, Herazo-Maya JD, Sennello JA, Flozak AS, Russell S, Mutlu GM, Budinger GR, DasGupta R, Varga J, Kaminski N, Gottardi CJ  Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.  Am J Respir Crit Care Med  2014 Jul 15;190(2):185-95. doi:10.1164/rccm.201401-0079OC
  22. Daugherty RL, Serebryannyy L, Yemelyanov A, Flozak AS, Yu HJ, Kosak ST, deLanerolle P, Gottardi CJ  α-Catenin is an inhibitor of transcription.  Proc Natl Acad Sci U S A  2014 Apr 08;111(14):5260-5. doi:10.1073/pnas.1308663111
  23. Ono M, Yin P, Navarro A, Moravek MB, Coon V JS, Druschitz SA, Gottardi CJ, Bulun SE  Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth.  Fertil Steril  2014 May;101(5):1441-9. doi:10.1016/j.fertnstert.2014.01.017
  24. Barry AK, Tabdili H, Muhamed I, Wu J, Shashikanth N, Gomez GA, Yap AS, Gottardi CJ, de Rooij J, Wang N, Leckband DE  α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction.  J Cell Sci  2014 Apr 15;127(Pt 8):1779-91. doi:10.1242/jcs.139014
  25. Lam AP, Gottardi CJ  Fat in fibrosis.  Am J Respir Crit Care Med  2013 Nov 15;188(10):1268-9. doi:10.1164/rccm.201305-0971LE
  26. Ono M, Yin P, Navarro A, Moravek MB, Coon JS, Druschitz SA, Serna VA, Qiang W, Brooks DC, Malpani SS, Ma J, Ercan CM, Mittal N, Monsivais D, Dyson MT, Yemelyanov A, Maruyama T, Chakravarti D, Kim JJ, Kurita T, Gottardi CJ, Bulun SE  Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.  Proc Natl Acad Sci U S A  2013 Oct 15;110(42):17053-8. doi:10.1073/pnas.1313650110
  27. Gottardi CJ, Königshoff M  Considerations for targeting β-catenin signaling in fibrosis.  Am J Respir Crit Care Med  2013 Mar 15;187(6):566-8. doi:10.1164/rccm.201301-0144ED
  28. Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, DeBerardinis RJ, Lavker RM, Chandel NS  Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.  Sci Signal  2013 Feb 05;6(261):ra8. doi:10.1126/scisignal.2003638
  29. Campos ML, Sánchez-Arévalo Lobo VJ, Rodolosse A, Gottardi CJ, Mafficini A, Beghelli S, Scardoni M, Bassi C, Scarpa A, Real FX  ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.  Biochem J  2013 May 01;451(3):395-405. doi:10.1042/BJ20120873
  30. McEwen AE, Escobar DE, Gottardi CJ  Signaling from the adherens junction.  Subcell Biochem  2012;60:171-96. doi:10.1007/978-94-007-4186-7_8
  31. Wei J, Fang F, Lam AP, Sargent JL, Hamburg E, Hinchcliff ME, Gottardi CJ, Atit R, Whitfield ML, Varga J  Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.  Arthritis Rheum  2012 Aug;64(8):2734-45. doi:10.1002/art.34424
  32. Jain M, Lam A, Gottardi CJ  Tissue-specific knockout/knockdown of type 2 TGF-β receptor and protection against bleomycin injury/fibrosis.  Am J Respir Crit Care Med  2011 Oct 15;184(8):983; author reply 983-4
  33. Lam AP, Gottardi CJ  β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target.  Curr Opin Rheumatol  2011 Nov;23(6):562-7. doi:10.1097/BOR.0b013e32834b3309
  34. Smith KA, Tong X, Abu-Yousif AO, Mikulec CC, Gottardi CJ, Fischer SM, Pelling JC  UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes.  Mol Carcinog  2012 Sep;51(9):734-45. doi:10.1002/mc.20840
  35. Zhou Q, Pardo A, Königshoff M, Eickelberg O, Budinger GR, Thavarajah K, Gottardi CJ, Jones J, Varga J, Selman M, Sznajder JI, Raj JU, Zhou G  Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis.  FASEB J  2011 Sep;25(9):3032-44. doi:10.1096/fj.10-177824
  36. Mirkovic I, Gault WJ, Rahnama M, Jenny A, Gaengel K, Bessette D, Gottardi CJ, Verheyen EM, Mlodzik M  Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin.  Nat Struct Mol Biol  2011 Jun;18(6):665-72. doi:10.1038/nsmb.2049
  37. Burkhalter RJ, Symowicz J, Hudson LG, Gottardi CJ, Stack MS  Integrin regulation of beta-catenin signaling in ovarian carcinoma.  J Biol Chem  2011 Jul 01;286(26):23467-75. doi:10.1074/jbc.M110.199539
  38. Lam AP, Gottardi CJ, Tuder R  Regenerative pathways and emphysema: a new paradigm?  Am J Respir Crit Care Med  2011 Mar 15;183(6):688-90. doi:10.1164/rccm.201011-1772ED
  39. Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ  Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.  Am J Respir Cell Mol Biol  2011 Nov;45(5):915-22. doi:10.1165/rcmb.2010-0113OC
  40. Wei J, Melichian D, Komura K, Hinchcliff M, Lam AP, Lafyatis R, Gottardi CJ, MacDougald OA, Varga J  Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?  Arthritis Rheum  2011 Jun;63(6):1707-17. doi:10.1002/art.30312
  41. Neumann S, Schneider M, Daugherty RL, Gottardi CJ, Eming SA, Beijer A, Noegel AA, Karakesisoglou I  Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.  J Biol Chem  2010 Nov 05;285(45):34932-8. doi:10.1074/jbc.M110.119651
  42. Maher MT, Mo R, Flozak AS, Peled ON, Gottardi CJ  Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling.  PLoS One  2010 Apr 16;5(4):e10184. doi:10.1371/journal.pone.0010184
  43. Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Mutlu GM, Budinger GR, Gottardi CJ  Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.  J Biol Chem  2010 Jan 29;285(5):3157-67. doi:10.1074/jbc.M109.070326
  44. Mo R, Chew TL, Maher MT, Bellipanni G, Weinberg ES, Gottardi CJ  The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.  J Biol Chem  2009 Oct 09;284(41):28222-31. doi:10.1074/jbc.M109.045039
  45. Verheyen EM, Gottardi CJ  Regulation of Wnt/beta-catenin signaling by protein kinases.  Dev Dyn  2010 Jan;239(1):34-44. doi:10.1002/dvdy.22019
  46. Maher MT, Flozak AS, Stocker AM, Chenn A, Gottardi CJ  Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion.  J Cell Biol  2009 Jul 27;186(2):219-28. doi:10.1083/jcb.200811108
  47. Maher MT, Flozak AS, Hartsell AM, Russell S, Beri R, Peled ON, Gottardi CJ  Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7.  Biol Direct  2009 Feb 02;4:5. doi:10.1186/1745-6150-4-5
  48. Jeanes A, Gottardi CJ, Yap AS  Cadherins and cancer: how does cadherin dysfunction promote tumor progression?  Oncogene  2008 Nov 24;27(55):6920-9. doi:10.1038/onc.2008.343
  49. Lal M, Song X, Pluznick JL, Di Giovanni V, Merrick DM, Rosenblum ND, Chauvet V, Gottardi CJ, Pei Y, Caplan MJ  Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling.  Hum Mol Genet  2008 Oct 15;17(20):3105-17. doi:10.1093/hmg/ddn208
  50. Padovan C, Bonfigli F, Ulessi B, Gottardi C, Giansante C, Trevisan G  Calciphylaxis of the breast: a rare disease in the differential diagnosis of breast cancer.  Acta Dermatovenerol Croat  2008;16(2):83-6