Northwestern University Feinberg School of Medicine

Daniel Foltz Lab

Our Lab

Our lab focuses on the important basic question of how chromosomes are segregated during cell division to ensure the complete and accurate inheritance of the genome. Centromeres are specified by the incorporation of a histone variant CENP-A, and stable inheritance of this locus is controlled by an epigenetic pathway. Determining the molecular mechanism responsible for the epigenetic inheritance is the major focus of the lab. Chromosome instability is a hallmark of cancer and can drive the formation of tumors. Therefore, how centromere specification is controlled is a basic biological question with great therapeutic potential.

Our long-term goal is to delineate the role of this process in tumorigenesis and translate our basic understanding of the enzymes and proteins involved in this process into therapeutic approaches for targeting proliferative disease. We use a combination of cell biology, biochemical purification, and in vitro reconstitution of centromeric chromatin to discover the mechanism of epigenetic inheritance and CENP-A function during mitosis.

Recent Publications

More Publications

Daniel R Foltz, PhD

Daniel R Foltz, PhD
Associate Professor in Biochemistry and Molecular Genetics

For more information, click here to visit our department page.

Postdoctoral Positions Available

Interested candidates please send your CV, a brief description of your research achievements and interests, and the name and contact details for three references to Daniel Foltz.