The DeCaen lab is located in the Searle building of the Feinberg School of Medicine in the heart of downtown Chicago.
The DeCaen lab is located in the Searle building of the Feinberg School of Medicine in the heart of downtown Chicago.
Primary cilia electrophysiology directly measures polycystin ion channel activity.
Primary cilia electrophysiology directly measures polycystin ion channel activity.
Primary cilia in the kidney collecting duct illuminated using genetically encoded Arl13b-GFP.
Primary cilia in the kidney collecting duct illuminated using genetically encoded Arl13b-GFP.
hERG (Human ether ago-go related gene) conducts delayed rectifying K+ currents essential for ventricular cardiomyocyte repolarization. Here, hERG potassium current is blocked by dofetilide, which can result in arrhythmias.
hERG (Human ether ago-go related gene) conducts delayed rectifying K+ currents essential for ventricular cardiomyocyte repolarization. Here, hERG potassium current is blocked by dofetilide, which can result in arrhythmias.
The structural components of ion channels give rise to their function: Pore domains (PD) which determines which ions pass though the channel. Voltage sensor domains (VSD) which determines if the channel will open in response to the membrane potential.
The structural components of ion channels give rise to their function: Pore domains (PD) which determines which ions pass though the channel. Voltage sensor domains (VSD) which determines if the channel will open in response to the membrane potential.
A single and a population of PKD2-L1 ion channel currents.
A single and a population of PKD2-L1 ion channel currents.
We are using electrophysiology methods in conjunction with advanced imaging techniques to explore ion channel physiology. Here, Leo Ng is measuring sodium currents from Nav1.1, with the goal of understanding seizures in epilepsy.
We are using electrophysiology methods in conjunction with advanced imaging techniques to explore ion channel physiology. Here, Leo Ng is measuring sodium currents from Nav1.1, with the goal of understanding seizures in epilepsy.
Sodium Channel Pharmacology. The lamotrigine (anticonvulsant) binding site in voltage gated sodium channels.
Sodium Channel Pharmacology. The lamotrigine (anticonvulsant) binding site in voltage gated sodium channels.
Our lab is growing and we are looking for talent.
Our lab is growing and we are looking for talent.

About Our Lab

We endeavor to characterize novel and medically relevant ion channels using biophysical, pharmacological and genetic techniques. Our goal is to understand ion channel relevance in cell biology and disease progression.

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Paul DeCaen Lab

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