Northwestern University Feinberg School of Medicine

Nicholas Cianciotto Lab


Learn more about the work that we do in the Nicholas Cianciotto Laboratory through our recent publications.
  1. White RC, Gunderson FF, Tyson JY, Richardson KH, Portlock TJ, Garnett JA, Cianciotto NP  Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition during Legionella pneumophila Intracellular Infection of Amoebas.  MBio  2018 04 17;9(2). pii:e00528-18
  2. Nas MY, Cianciotto NP  Stenotrophomonas maltophilia produces an EntC-dependent catecholate siderophore that is distinct from enterobactin.  Microbiology  2017 11;163(11):1590-1603. doi:10.1099/mic.0.000545
  3. DuMont AL, Cianciotto NP  Stenotrophomonas maltophilia Serine Protease StmPr1 Induces Matrilysis, Anoikis, and Protease-Activated Receptor 2 Activation in Human Lung Epithelial Cells.  Infect Immun  2017 12;85(12). pii:e00544-17
  4. Truchan HK, Christman HD, White RC, Rutledge NS, Cianciotto NP  Type II Secretion Substrates of Legionella pneumophila Translocate Out of the Pathogen-Occupied Vacuole via a Semipermeable Membrane.  MBio  2017 06 20;8(3). pii:e00870-17
  5. Cianciotto NP, White RC  Expanding Role of Type II Secretion in Bacterial Pathogenesis and Beyond.  Infect Immun  2017 05;85(5). pii:e00014-17
  6. Mallama CA, McCoy-Simandle K, Cianciotto NP  The Type II Secretion System of Legionella pneumophila Dampens the MyD88 and Toll-Like Receptor 2 Signaling Pathway in Infected Human Macrophages.  Infect Immun  2017 04;85(4). pii:e00897-16
  7. White RC, Cianciotto NP  Type II Secretion Is Necessary for Optimal Association of the Legionella-Containing Vacuole with Macrophage Rab1B but Enhances Intracellular Replication Mainly by Rab1B-Independent Mechanisms.  Infect Immun  2016 Dec;84(12):3313-3327
  8. O'Connor TJ, Zheng H, VanRheenen SM, Ghosh S, Cianciotto NP, Isberg RR  Iron Limitation Triggers Early Egress by the Intracellular Bacterial Pathogen Legionella pneumophila.  Infect Immun  2016 08;84(8):2185-2197. doi:10.1128/IAI.01306-15
  9. Aubi O, Flydal MI, Zheng H, Skjærven L, Rekand I, Leiros HK, Haug BE, Cianciotto NP, Martinez A, Underhaug J  Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila.  J Med Chem  2015 Nov 12;58(21):8402-12. doi:10.1021/acs.jmedchem.5b01589
  10. Burnside DM, Wu Y, Shafaie S, Cianciotto NP  The Legionella pneumophila Siderophore Legiobactin Is a Polycarboxylate That Is Identical in Structure to Rhizoferrin.  Infect Immun  2015 Oct;83(10):3937-45. doi:10.1128/IAI.00808-15
  11. DuMont AL, Karaba SM, Cianciotto NP  Type II Secretion-Dependent Degradative and Cytotoxic Activities Mediated by Stenotrophomonas maltophilia Serine Proteases StmPr1 and StmPr2.  Infect Immun  2015 Oct;83(10):3825-37. doi:10.1128/IAI.00672-15
  12. Cianciotto NP  An update on iron acquisition by Legionella pneumophila: new pathways for siderophore uptake and ferric iron reduction.  Future Microbiol  2015;10(5):841-51. doi:10.2217/fmb.15.21
  13. Gunderson FF, Mallama CA, Fairbairn SG, Cianciotto NP  Nuclease activity of Legionella pneumophila Cas2 promotes intracellular infection of amoebal host cells.  Infect Immun  2015 Mar;83(3):1008-18. doi:10.1128/IAI.03102-14
  14. Tyson JY, Vargas P, Cianciotto NP  The novel Legionella pneumophila type II secretion substrate NttC contributes to infection of amoebae Hartmannella vermiformis and Willaertia magna.  Microbiology  2014 Dec;160(Pt 12):2732-44. doi:10.1099/mic.0.082750-0
  15. Portier E, Zheng H, Sahr T, Burnside DM, Mallama C, Buchrieser C, Cianciotto NP, Héchard Y  IroT/mavN, a new iron-regulated gene involved in Legionella pneumophila virulence against amoebae and macrophages.  Environ Microbiol  2015 Apr;17(4):1338-50. doi:10.1111/1462-2920.12604
  16. Zheng H, Chatfield CH, Liles MR, Cianciotto NP  Secreted pyomelanin of Legionella pneumophila promotes bacterial iron uptake and growth under iron-limiting conditions.  Infect Immun  2013 Nov;81(11):4182-91. doi:10.1128/IAI.00858-13
  17. Cianciotto NP  Type II secretion and Legionella virulence.  Curr Top Microbiol Immunol  2013;376:81-102. doi:10.1007/82_2013_339
  18. Karaba SM, White RC, Cianciotto NP  Stenotrophomonas maltophilia encodes a type II protein secretion system that promotes detrimental effects on lung epithelial cells.  Infect Immun  2013 Sep;81(9):3210-9. doi:10.1128/IAI.00546-13
  19. Chaudhuri S, Gantner BN, Ye RD, Cianciotto NP, Freitag NE  The Listeria monocytogenes ChiA chitinase enhances virulence through suppression of host innate immunity.  MBio  2013 Mar 19;4(2):e00617-12. doi:10.1128/mBio.00617-12
  20. Gunderson FF, Cianciotto NP  The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae.  MBio  2013 Mar 12;4(2):e00074-13. doi:10.1128/mBio.00074-13
  21. Tyson JY, Pearce MM, Vargas P, Bagchi S, Mulhern BJ, Cianciotto NP  Multiple Legionella pneumophila Type II secretion substrates, including a novel protein, contribute to differential infection of the amoebae Acanthamoeba castellanii, Hartmannella vermiformis, and Naegleria lovaniensis.  Infect Immun  2013 May;81(5):1399-410. doi:10.1128/IAI.00045-13
  22. Chatfield CH, Cianciotto NP  Culturing, media, and handling of legionella.  Methods Mol Biol  2013;954:151-62. doi:10.1007/978-1-62703-161-5_7