Northwestern University Feinberg School of Medicine

Jindan Yu Lab

What We Do

Our laboratory focuses on understanding the genetic and epigenetic pathways to prostate cancer. A number of key transcription factors, including the Androgen Receptor, the Polycomb group protein EZH2, and the TMPRSS2:ERG gene fusions,  have been related to epigenetic changes and implicated in prostate cancer. However, their downstream pathways remain largely unknown. Using 'omics' approaches we have identified a number of target genes and molecular pathways of these transcription factors. Our study will elucidate the specific pathways of these transcription factors and how they may crosstalk with each other to form an intertwined network. Findings from our study will then be applied to understand the hormone-refractory prostate tumors and help the design of novel therapeutic targets.

News

03/20/2017: New paper published in Oncogene: FOXA1 inhibits prostate cancer neuroendocrine differentiation.

03/07/2017: New paper published in Cell Reports:  CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.

02/01/2017: Nathan Damaschke joined the lab as a postdoctoral fellow. Welcome Nate!

11/04/2016: New paper published in Cancer Research: Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer.

09/01/2016: New postdoc Dr. Yongik Lee started in the lab. Welcome Yongik!

08/31/2016: Dr. Jung Kim has graduated and moved back to Maryland to join NCI as a CRTA fellow at DCEG. Congratulations, Jung.

08/26/2016: DGP graduate student Kevin Park joined the lab. Welcome, Kevin!

07/26/2016: Will is awarded Katten Muchin Rosenman award. Congratulations!

07/12/2016: Will is selected to receive the Heme/Onc division Rizvi travel award. Congratulations!

06/07/2016: New paper published in Mol Endocrinol: KAT8 regulates androgen signaling in prostate cancer cells.

06/01/2016: New paper published in Nucleic Acids Research: FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.

05/04/2016: New paper published in BMC Genomics: The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.

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    Recent Publications

    Kim J, Jin H, Zhao JC, Yang YA, Li Y, Yang X, Dong X, Yu J. FOXA1 inhibits prostate cancer neuroendocrine differentiation.  Oncogene. 2017 March 20. PMID: 28319070

    Qadir AS, Ceppi P, Brockway S, Law C, Mu L, Khodarev NN, Kim J, Zhao JC, Putzbach W, Murmann AE, Chen Z, Chen W, Liu X, Salomon AR, Liu H, Weichselbaum RR, Yu J, Peter ME.  CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.  Cell Rep. 2017 March 07. PMID: 28273453

    Fong KW, Zhao JC, Kim J, Li S, Yang YA, Song B, Rittie L, Hu M, Yang X, Perbal B, Yu J. Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer.  Cancer Res. 2016 Nov 4. PMID: 27815387

    Kim JY, Yu J, Abdulkadir SA, Chakravarti D. KAT8 regulates androgen signaling in prostate cancer cells.  Mol Endocrinol. 2016 June 07. PMID: 27257062

    Yang YA, Zhao JC, Fong KW, Kim J, Li S, Song C, Song B, Zheng B, He C, Yu J. FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.  Nucleic Acids Res. 2016 June 01. PMID: 27268279

    Zhao JC, Li XY, Guo MX, Yu J, Yan C. The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.  BMC Genomics. 2016 May 04. PMID: 27146783

    Zhao JC, Fong KW, Jin HJ, Yang YA, Kim J, Yu J. FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.  Oncogene. 2016 Jan 11. PMID: 26751772

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    yu

    Jindan Yu, MD, PhD

    Associate Professor of Medicine (Hematology/Oncology) and Biochemistry and Molecular Genetics

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