What We Do

Our laboratory focuses on understanding the genetic and epigenetic pathways to prostate cancer. A number of key transcription factors, including the Androgen Receptor, the Polycomb group protein EZH2, and the TMPRSS2:ERG gene fusions,  have been related to epigenetic changes and implicated in prostate cancer. However, their downstream pathways remain largely unknown. Using 'omics' approaches we have identified a number of target genes and molecular pathways of these transcription factors. Our study will elucidate the specific pathways of these transcription factors and how they may crosstalk with each other to form an intertwined network. Findings from our study will then be applied to understand the hormone-refractory prostate tumors and help the design of novel therapeutic targets.

News

07/26/2016: Will is awarded Katten Muchin Rosenman award. Congratulations!

07/12/2016: Will is selected to receive the Heme/Onc division Rizvi travel award. Congratulations!

06/07/2016: New paper published in Mol Endocrinol: KAT8 regulates androgen signaling in prostate cancer cells.

06/01/2016: New paper published in Nucleic Acids Research: FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.

05/04/2016: New paper published in BMC Genomics: The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.

01/11/2016: New paper published in Oncogene: FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.

12/18/2015: Harsha has successfully graduated from the Northwestern MBP program. Congratulations!

12/13/2015: Xiaodong Lu joined the lab as a postdoctoral fellow. Welcome Xiaodong!

10/20/2015: New paper published in Oncotarget: miR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition.

09/24/2015: New paper published in Cell Reports: LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer.

09/18/2015: New paper published in Oncogene: LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer.

09/01/2015: Jung graduated and joined the lab as a postdoctoral fellow. Congratulations and Welcome again!

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    Recent Publications

    Kim JY, Yu J, Abdulkadir SA, Chakravarti D. KAT8 regulates androgen signaling in prostate cancer cells.  Mol Endocrinol. 2016 June 07. PMID: 27257062

    Yang YA, Zhao JC, Fong KW, Kim J, Li S, Song C, Song B, Zheng B, He C, Yu J. FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.  Nucleic Acids Res. 2016 June 01. PMID: 27268279

    Zhao JC, Li XY, Guo MX, Yu J, Yan C. The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.  BMC Genomics. 2016 May 04. PMID: 27146783

    Zhao JC, Fong KW, Jin HJ, Yang YA, Kim J, Yu J. FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.  Oncogene. 2016 Jan 11. PMID: 26751772

    Wang L, Song G, Tan W, Qi M, Zhang L, Chan J, Yu J, Han J, Han B. miR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition.  Oncotarget. 2015 Oct 03. PMID: 26451614

    Zhang A, Zhao JC, Kim J, Fong KW, Yang YA, Chakravarti D, Mo YY, Yu J. LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer.  Cell Reports. 2015 Aug.

    Shen S, Guo X, Yan H, Lu Y, Ji X, Li L, Liang T, Zhou D, Feng XH, Zhao JC, Yu J, Gong XG, Zhang L, Zhao B. A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis. Cell Res. 2015 Aug 14. PMID: 26272168

     Xue XY, Yang YA, Zhang A, Fong KW, Kim J, Song B, Li S, Zhao JC, Yu J. LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer.  Oncogene. 2015 Sep 14. PMID: 26364613 [Epub ahead of print]

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    yu

    Jindan Yu, MD, PhD

    Associate Professor in Medicine-Hematology/Oncology

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