About Our Lab
The overarching goal of Wan laboratory, within the Department of Obstetrics and Gynecology at Northwestern University Feinberg School of Medicine in Chicago, is to define the molecular mechanisms of breast tumor initiation, progression, and metastasis, and to identify novel targets for therapeutic development. Particularly, the laboratory seeks to address how defects in the ubiquitin-proteasome system and other posttranslational modifiers such as protein methyltransferase and poly (ADP-ribose) polymerase would result in genomic instability, abnormal cell cycle, and aberrant signaling that predispose otherwise normal cells to become cancerous tumor cells or promote cancer metastasis.
- Zhou Z, Shrivastava I, Lou A, He M, Huang Y, Liu Z, Bahar I and Wan Y. 2017. Novel insight into USP11-XIAP axis in malignant tumor transformation. EBioMedicine. Feb;15:48-61. PMID:28040451
- Hu D, Gur M, Zhou Z, Gamper A, Hung MC, Fujita N, Lan L, Bahar I and Wan Y. 2015 Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. Sep 30;6:8419. PMID: 26420673
- Gamper A., Kim J., Qiao X. Rathmell K. and Wan Y. 2012. Proteolytic regulation of Krüppel-like Factor 4 (KLF4) by VHL E3 ligase in breast carcinogenesis. Mol Cell. Jan 27;45(2):233-43. PMID: 22284679