Northwestern University Feinberg School of Medicine

Wainwright Laboratory of Tumor- and Neuro-immunology

Publications

2017

Wainwright DA, Horbinski C, Hashizume R, James CD. 2017. Therapeutic hypothesis testing with rodent brain tumor models. Neurotherapeutics. In Press.

Zhai L, Ladomersky E, Dostal CR, Lauing KL, Swoap K, Billingham LK, Gritsina G, Wu M, McCusker RH, Binder DC, Wainwright DA. 2017. Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma. Brain, Behavior and Immunity. In Press. PMID: 28179106

2016

Lenzen A, Zhai L, Lauing KL, Gritsina G, Ladomersky E, Genet M, James CD, Bloch O, Wainwright DA. 2016. The kynurenine/tryptophan ratio and glioblastoma patients treated with HSPPC-96 vaccine. Immunotherapy. PMID: 27819068

Ladomersky E, Zhai L, Gritsina G, Genet M, Lauing KL, Wu M, James CD, Wainwright DA. 2016. Advanced age negatively impacts survival in an experimental brain tumor model. Neuroscience Letters. PMID: 27493076

Ladomersky E, Genet M, Zhai L, Gritsina G, Lauing KL, Lulla RR, Fangusaro J, Lenzen A, Kumthekar P, Raizer JJ, Binder DC, James CD, Wainwright DA. 2016. Improving Vaccine Efficacy Against Malignant Glioma. Oncoimmunology. PMID: 27622066

Binder DC, Arina A, Wen F, Tu T, Zhao M, Hoffman RM, Wainwright DA, Schreiber H. 2016. Adoptive T cell therapy combined with bacterial loading prevents recurrent tumors. Oncoimmunology. In Press.

Klarquist J, Eby JM, Henning SW, Li M, Wainwright DA, Westerhof W, Luiten RM, Nishimura MI, Le Poole IC. 2016. Functional cloning of a gp100-reactive T cell receptor from vitiligo patient skin. Pigment Cell & Melanoma Research. [Epub ahead of print] PMID: 26824221

Lukas RV, Wainwright DA, Laterra JJ. 2016. Updates from the Neuro-Oncology Section of the 2015 American Neurological Association Annual Meeting. Future Oncology – Future Medicine. 12(2):143-7. PMID: 26616737

2015

Zhai L, Spranger S, Binder DC, Gritsina G, Lauing KL, Giles FJ,  Wainwright DA. 2015. Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy. Clinical Cancer Research. 21(24):5427-33. PMID: 26519060

Binder DC, Davis AA, Wainwright DA. 2015. Immunotherapy for cancer in the central nervous system: current and future directions. 5(2):e1082027OncoImmunologyPMID: 27057463

Zhai L, Dey M, Lauing KL, Gritsina G, Kaur R, Lukas RV, Nicholas MK, Rademaker AW, Dostal CR, McCusker RH, Raizer JJ, Parsa AT, Bloch O, Wainwright DA. 2015. Assessing the Kynurenine to Tryptophan Ratio as a Prognostic Tool for Glioblastoma Patients Enrolling in Immunotherapy. Journal of Clinical Neuroscience. S0967-5868(15)00358-6. PMID: 26279502

Zhai L, Lauing KL, Chang AL, Dey M, Qian J, Cheng Y, Lesniak MS, Wainwright DA. 2015. The role of IDO in brain tumor immunotherapy. Journal of Neuro-oncology. 123(3):395-403. PMID: 25519303

Dey M, Chang AL, Miska J, Wainwright DA, Ahmed AU, Balyasnikova IV, Pytel P, Han Y, Tobias A, Zhang L, Qiao J, Lesniak MS. 2015. Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma. Journal of Immunology. 195(1):367-76. PMID: 26026061

Gritsina G, Xiao F, O'Brien SW, Gabbasov R, Maglaty MA, Xu RH, Thapa RJ, Zhou Y, Nicolas E, Litwin S, Balachandran S, Sigal LJ, Huszar D, Connolly DC. 2015. Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. Molecular Cancer Therapeutics. 14(4):1035-47. PMID: 25646015

Ladomersky E, Petris MJ. 2015. Copper tolerance and virulence in bacteria. Metallomics. 7(6):957-64. PMID: 25652326

Hodgkinson VL, Zhu S, Wang Y, Ladomersky E, Nickelson K, Weisman GA, Lee J, Gitlin JD, Petris MJ. 2015. Autonomous requirements of the Menkes disease protein in the nervous system. Cell Physiology – American Journal of Physiology. 309(10):C660-8. PMID: 26269458

McMillan DD, Maeda J, Bell JJ, Genet MD, Phoonswadi G, Mann KA, Kraft SL, Kitamura H, Fujimori A, Yoshii Y, Furukawa T, Fujibayashi Y, Kato TA. 2015. Validation of 64Cu-ATSM damaging DNA via high-LET Auger electron emission. Journal of Radiation Research. 56(5):784-91. PMID: 26251463

Liu XS, Genet MD, Haines JE, Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE, Pandolfi PP, Yuan ZM. 2015. ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM. Molecular Cancer Research. 13(8):1206-17. PMID: 25995384

Cartwright IM, Bell JJ, Maeda J, Genet MD, Romero A, Fujii Y, Fujimori A, Kitamuta H, Kamada T, Chen DJ, Kato TA. 2015. Effects of targeted phosphorylation site mutations in the DNA-PKcs phosphorylation domain on low and high LET radiation sensitivity. Oncology Letters. 9(4):1621-1627. PMID: 25789011

2014

Wainwright DA, Lesniak MS. Ménage à trois: Sustained therapeutic anti-tumor immunity requires multiple partners in malignant glioma. Oncoimmunology. 15;3:e28927. PMID: 25057450

Wainwright DA, Chang AL, Dey M, Balyasnikova IV, Kim C, Tobias AL, Cheng Y, Kim J, Zhang L, Qiao J, Han Y, Lesniak MS. 2014 Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4 and PD-L1 in mice with brain tumors. Clinical Cancer Research. 20(20):5290-301. PMID:  24691018

Cheng Y, Dai Q, Morshed RA, Fan X, Wegscheid ML, Wainwright DA, Han Y, Zhang L, Auffinger B, Tobias AL, Rincón E, Thaci B, Ahmed AU, Warnke PC, He C, Lesniak MS. 2014. Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging. Small. 10(24):5137-50. PMID: 25104165

Thaci B, Ahmed AU, Ulasov IV, Wainwright DA, Nigam P, Auffinger B, Tobias AL, Han Y, Zhang L, Moon KS, Lesniak MS. 2014. Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma. Cancer Gene Ther. 21(1):38-44. doi: 10.1038/cgt.2013.81. PMID: 24434573

Dey M, Chang AL, Wainwright DA, Ahmed AU, Han Y, Balyasnikova IV, Lesniak MS. 2014. Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model. Journal of Neuroimmunology. 266(1-2):33-42. PMID: 24268287

Chung EJ, Cheng Y, Morshed R, Nord K, Han Y, Wegscheid ML, Auffinger B, Wainwright DA, Lesniak MS, Tirrell MV. 2014. Fibrin-binding, peptide amphiphile micelles for targeting glioblastoma. Biomaterials. 35(4):1249-56. PMID: 24211079  

Lauing KL, Sundaramurthy S, Nauer RK, Callaci JJ. 2014. Exogenous activation of Wnt/β-catenin signaling attenuates binge alcohol-induced deficient bone fracture healing. Alcohol Alcohol. 49(4):399-408. PMID: 24627571

Lauing KL, Cortes M, Domowicz MS, Henry JG, Baria AT, Schwartz NB. 2014. Aggrecan is required for growth plate cytoarchitecture and differentiation. Developmental Biology. 396(2):224-36. PMID: 25446537

Maeda J, Bell JJ, Genet SC, Fujii Y, Genet MD, Brents CA, Genik PC, Kato TA. 2014. Potentially lethal damage repair in drug arrested G2-phase cells after radiation exposure. Radiation Research. 182(4):448-57. PMID: 25251700

Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. 2014. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes and Development. PMID: 25184678

Cartwright IM, Genet MD, Fujimori A, Kato TA. 2014. Role of LET and chromatin structure on chromosomal inversion in CHO10B2 cells. Genome Integrity. 5(1):1. PMID: 24467838

2013

Wainwright DA, Dey M, Chang A, Lesniak MS. 2013 Targeting Tregs in Malignant Brain Cancer: Overcoming IDO. Frontiers in Immunology 4:116. PMID: PMC3654236

Cheng Y, Morshed R, Cheng SH, Tobias A, Auffinger B, Wainwright DA, Zhang L, Yunis C, Han Y, Chen CT, Lo LW, Aboody KS, Ahmed AU, Lesniak MS. 2013. Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. Small. 9(24):4123-9. PMID: 23873826

Cappello T, Nuelle JA, Katsantonis N, Nauer RK, Lauing KL, Jagodzinski JE, Callaci JJ. 2013. Ketorolac administration does not delay early fracture healing in a juvenile rat model: a pilot study. Journal of Pediatric Orthopaedics. 33(4):415-21. PMID: 23653032

Genet MD, Cartwright IM, Kato Ta. 2013. Direct DNA and PNA probe binding to telomeric regions without classical in situ hybridization. Molecular Cytogenetics. 6(1):42. PMID: 24103162

Fujii Y, Genet MD, Roybal EJ, Kubota N, Okayasu R, Miyagawa K, Fujimori A, Kato TA. 2013. Comparison of the bromodeoxyuridine-mediated sensitization effects between low-LET and high-LET ionizing radiation on DNA double-strand breaks. Oncology Reports. 2013 29(6):2133-9. PMID: 23525528

Genet SC, Fujii Y, Maeda J, Kaneko M, Genet MD, Miyagawa K, Kato TA. 2013. Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner. Journal of Cellular Physiology. 228(7):1473-81. PMID: 23254360

Cartwright IM, Genet MD, Kato TA. 2013. A simple and rapid fluorescence in situ hybridization microwave protocol for reliable dicentric chromosome analysis. Journal of Radiation Research. 2013 54(2):344-8. PMID: 23161278

2012

Wainwright DA, Balyasnikova IV, Chang AL, Ahmed AU, Moon KS, Auffinger B, Tobias AL, Han Y, Lesniak MS. 2012 IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival. Clinical Cancer Research 18(22):6110-21. PMID: 22932670

Wainwright DA, Nigam P, Thaci B, Dey M, Lesniak MS. 2012 Recent developments on immunotherapy for brain cancer. Expert Opinion on Emerging Drugs 17(2):181-202. PMID: 22533851

Balyasnikova IV,  Wainwright DA, Solomaha E, Lee G, Han Y, Thaci B, Lesniak MS. 2012. Characterization and immunotherapeutic implications for a novel antibody targeting interleukin (IL)-13 receptor α2. Journal of Biological Chemistry. 287(36):30215-27. PMID: 22778273

Xin J, Mesnard NA, Beahrs T,  Wainwright DA, Serpe CJ, Alexander TD, Sanders VM, Jones KJ. 2012. CD4+ T cell-mediated neuroprotection is independent of T cell-derived BDNF in a mouse facial nerve axotomy model. Brain, Behavior, and Immunity. 26(6):886-90. PMID: 22426430

Zhai LWang TKang KZhao YShrotriya PNilsen-Hamilton M. 2012. An RNA aptamer-based microcantilever sensor to detect the inflammatory marker, mouse lipocalin-2. Analytical Chemistry. 84(20):8763-70. 

Lauing KL, Roper PM, Nauer RK, Callaci JJ. 2012. Acute alcohol exposure impairs fracture healing and deregulates β-catenin signaling in the fracture callus. Alcoholism: Clinical and Experimental Research. 36(12):2095-103. PMID: 22691115

2011

Wainwright DA, Sengupta S, Han Y, Lesniak MS. 2011. Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors. Neuro-Oncology 13(12):1308-23. PMID: 21908444

Wainwright DA, Balyasnikova IV, Han Y, Lesniak MS. 2011. The expression of BST2 in human and experimental mouse brain tumors. Experimental and Molecular Pathology 91(1):440-6. PMID: 21908444

Thaci B, Ulasov IV,  Wainwright DA, Lesniak MS. 2011. The challenge for gene therapy: innate immune response to adenoviruses. Oncotarget. 2011 2(3):113-21. PMID: 21399236

Xin J,  Wainwright DA, Mesnard NA, Serpe CJ, Sanders VM, Jones KJ. 2011. IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection. Brain, Behavior, and Immunity. 25(5):820-9. PMID: 20723599

Volkmer DL, Sears B,  Lauing KL, Nauer RK, Roper PM, Yong S, Stover M, Callaci JJ. 2011. Antioxidant therapy attenuates deficient bone fracture repair associated with binge alcohol exposure. Journal of Orthopaedic Trauma. 25(8):516-21. PMID: 21738068

Jung MK, Callaci JJ,  Lauing KL, Otis JS, Radek KA, Jones MK, Kovacs EJ. 2011. Alcohol exposure and mechanisms of tissue injury and repair. Alcoholism: Clinical and Experimental Research. 35(3):392-9. PMID: 21118273

2010

Wainwright DA, Sengupta S, Han Y, Ulasov IV, Lesniak MS. 2010. The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma. PLoS One 2010 Oct 23;5(10):e15390. PMID: 21060663

Wainwright DA, Xin J, Mesnard NA, Sanders VM, Jones KJ. 2010. Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy. Neuroscience Letters. 471(1):10-4. PMID: 20056129 

Sengupta S, Nandi S, Hindi ES, Wainwright DA, Han Y, Lesniak MS. 2010. Short hairpin RNA-mediated fibronectin knockdown delays tumor growth in a mouse glioma model. Neoplasia. 12(10):837-47. PMID: 20927322

Ahmed AU, Rolle CE, Tyler MA, Han Y, Sengupta S, Wainwright DA, Balyasnikova IV, Ulasov IV, Lesniak MS. 2010. Bone marrow mesenchymal stem cells loaded with an oncolytic adenovirus suppress the anti-adenoviral immune response in the cotton rat model. Molecular Therapeutics. 18(10):1846-56. PMID: 20588259

Klarquist J, Denman CJ, Hernandez C, Wainwright DA, Strickland FM, Overbeck A, Mehrotra S, Nishimura MI, Le Poole IC. 2010. Reduced skin homing by functional Treg in vitiligo. Pigment Cell & Melanoma Research. 23(3):477. PMID: 20175879

2009

Wainwright DA, Mesnard NA, Xin J, Sanders VM, Jones KJ. 2009 Effects of facial nerve axotomy on Th2-associated and Th1-associated chemokine mRNA expression in the facial motor nucleus of wild-type and presymptomatic SOD1 mice. Journal of Neurodegeneration and Regeneration 2(1):39-44. PMID: 20436785

Wainwright DA, Xin J, Mesnard NA, Beahrs TR, Politis CM, Sanders VM, Jones KJ. 2009 Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice. ASN Neuro 1(5):e00024. PMCID: PMC2826103

Wainwright DA, Xin J, Mesnard NA, Politis CM, Sanders VM, Jones KJ. 2009 Effects of facial nerve axotomy on Th2- and Th1-associated chemokine expression in the facial motor nucleus of wild-type and presymptomatic mSOD1 mice. Journal of Neuroimmunology 216(1-2):66-75. PMID: 19818514

2008

Wainwright DA, Xin J, Sanders VM, Jones KJ. 2008 Differential actions of pituitary adenylyl cyclase-activating polypeptide and interferon gamma on Th2- and Th1-associated chemokine expression in cultured murine microglia. Journal of Neurodegeneration and Regeneration 1(1):31-34. PMCID: PMC2864491

Xin J, Wainwright DA, Serpe CJ, Sanders VM, Jones KJ. 2008. Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy. Brain, Behavior, and Immunity. 22(4):528-37. PMID: 18024079