About Our Lab
Accurate chromosome segregation requires the successful and error-free association between kinetochores of the chromosomes and the plus-ends of microtubules of the mitotic spindle. Errors in this event lead to chromosome loss and aneuploidy which is a hallmark of cancer cells and leads to birth defects during human embryonic development. Research in the past several years has provided conclusive evidence that the Ndc80 kinetochore complex is crucial for this process but we still do not clearly understand how this complex is coupled to dynamic microtubule plus-ends during mitotic metaphase and anaphase in vertebrate cells.
We also do not have an accurate picture of how the kinetochore microtubule attachment mechanisms are coordinated seamlessly with the spindle assembly checkpoint, the essential surveillance mechanism that controls the fidelity of the chromosome segregation process. Studying the intricacies of these mutually linked phenomena will not only provide valuable information pertaining to the understanding of cancer initiation and progression but also lead to the identification of novel biomarkers and targets which in turn is likely to yield better diagnostic and therapeutic tools to combat this dreaded disease.
The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells.
Caldas GV, Lynch TR, Anderson R, Afreen S, Varma D*, DeLuca JG*.
Open Biol. 2015 Nov;5(11). pii: 150160.
How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.
Agarwal S, Varma D.
Bioarchitecture. 2015 Oct 2:1-12. [Epub ahead of print]
Sequential replication-coupled destruction at G1/S ensures genome stability.
Coleman KE, Grant GD, Haggerty RA, Brantley K, Shibata E, Workman BD, Dutta A, Varma D, Purvis JE, Cook JG.
Genes Dev. 2015 Aug 15;29(16):1734-46. doi:10.1101/gad.263731.115. Epub 2015 Aug 13.
Cell division: Molecular pathways for KMN kinetochore recruitment
Afreen S., Vama D.
Curr Biol. 2015 Apr 20;25(8):R332-5. doi: 10.1016/j.cub.2015.02.041.
06.15.2016 - Suchi's last day
04.01.2016 - Summer intern Natasha joins the lab
11.05.2015 - Sana/Dileep Open Biology paper published
10.02.2015 - Shivangi/Dileep Bioarchitecture review published
09.22.2015 - Amin joins the lab
06.15.2015 - Suchi joins the lab
06.01.2015 - Shivangi joins the lab
05.29.2015 - Liz's last day
04.20.2015 - Sana/Dileep’s dispatch published
04.01.2015 - Liz joins the lab
01.25.2015 - Sana joins the lab
01.01.2015 - Unofficial start date
12.03.2014 - Official Varma Lab start date