Northwestern University Feinberg School of Medicine

Jacob Sznajder Lab

About Our Lab

Our laboratory utilizes interdisciplinary approaches to study mechanisms of lung injury.  A focus is on the role that the linear ubiquitination assembly complex (LUBAC) and Na,K-ATPase play during influenza A pneumonitis. 

Another focus is on the sensing and effects of high CO2 (hypercapnia) in the lungs leading to lung and muscle dysfunction. 

We also study lung injury and proteostasis which encompasses cellular processes that regulate protein folding, misfolding, unfolding, degradation and repair. Our studies suggest that signals from the injured lung during IAV infection disrupt skeletal muscle proteostasis as a consequence of diminished proteostatic reserve in cells responsible for regenerating the damaged skeletal muscle.

External Collaborators

Aaron Ciechanover, MD, DSc
Technion-Israel Institute of Technology 

Susanne Herold, MD, PhD
Justus-Leibig Universitat Giessen

Esther Barreiro, MD
Institut Hospital del Mar d’Investigacions Mediques

Eoin Cummins, PhD
University College Dublin Conway Institute of Biomolecular and Biomedical Research, Dublin Ireland

Yosef Gruenbaum, PhD
The Hebrew University of Jerusalem

Cormac Taylor, PhD
University College Dublin Conway Institute of Biomolecular and Biomedical Research, Dublin Ireland

Istvan Vadasz, MD
Justus-Leibig Universitat Giessen, Giessen, Germany

Olga Vagin, PhD
University of California, Los Angeles

Jacob I Sznajder, MD

Jacob I Sznajder, MD
Professor, Division of Medicine-Pulmonary
Ernest S. Bazley Professor of Asthma and Related Disorders
Professor in Medicine-Pulmonary and Cell and Molecular Biology

For more information, click here to visit our department page.