Northwestern University   |   The Robert H. Lurie Comprehensive Cancer Center

Alexander H. Stegh, PhD
Assistant Professor - Zell Scholar
Department of Neurology
Phone: 312.503.2879
Fax: 312.503.5607

Robert H. Lurie Comprehensive Cancer Center
Northwestern University Feinberg School of Medicine
Center for Genetic Medicine, Lurie Rm. 6-109 and 6-250 (lab)
303 E. Superior Street, Chicago, IL 60611-3015

Our research program is aimed at understanding the genetic program that underlies the pathogenesis of Glioblastoma multiforme (GBM), the most prevalent and malignant form of brain cancer. Applying a combination of cell/molecular biology, oncogenomic and mouse engineering approaches, we are dedicated to systematically characterize novel gliomagenic oncogenes and tumor suppressors. We will functionally delineate and validate these pathways towards pharmaceutical opportunities using sophisticated cell culture and animal models. More...

Please read out latest publications, which received a lot of media attention (US News, FoxNews, Genetic Engineering & Biotechnology News, WGNTV, Chicago Tribune, Chicago Sun-Times, Chemical & Engineering News, Neurology Today, Science, Nature Medicine, Molecular Therapy)

Jensen et al. 2013: Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma. Sci Transl Med. 2013 Oct 30;5(209):209ra152.

See also an interview with Dr. Stegh on WGNTV.

Alexander H. Stegh. Integr Biol (Camb). 2012 Dec 17;5(1):48-65. Toward personalized cancer nanomedicine - past, present, and future.

Dr. Stegh received the 2012 Young Investigator Award of the Alliance For Cancer Gene Therapy.

Stegh laboratory assumes leadership role in Northwestern’s Center of Cancer Nanotechnology Excellence Grant (NU-CCNE U54). Read more at