Northwestern University Feinberg School of Medicine

Saratsis Pediatric Brain Tumor Laboratory

Our Mission

Our lab studies the biology of pediatric brain tumors to identify and test novel molecular targets for more effective therapies. Our overarching research goal is to identify biomarkers of disease and develop new therapeutic strategies to improve clinical outcomes for children with brain tumors. Read more about our work

News & Events

Meet Dr. Saratsis, featured in this video from Lurie Children’s Hospital

Dr. Saratsis’s lab has detected pediatric brain tumor mutations in cerebrospinal fluid.  These findings were published in April in Acta Neuropathologica Communtications.  Dr. Saratsis describes these findings here

Dr. Saratsis and Dr. Rishi Lulla (pediatric neuro-oncology) were awarded the 2017 Pediatric Cancer Research Foundation Emerging Research Grant for their research investigating epigenetic factors contributing to pediatric malignant glioma formation. Read more about this project here

Congratulations to Tina Huang for being selected as a finalist in the 13th Annual Lewis Landsberg Research Day at Northwestern Feinberg School of Medicine for her project, Epigenetic Analysis of Formalin-Fixed Paraffin-Embedded Pediatric Glioma Tissue

Congratulations to Tina Huang for selection of her project, Epigenetic Analysis of Formalin-Fixed Paraffin-Embedded Pediatric Glioma Tissue, to be presented at the 4th Biennial Society for Neuro-Oncology Pediatric Neuro-Oncology Basic and Translational Research Conference

Congratulations to Jin Qi for selection of her project, In Vitro and in Vivo analysis of Tenascin-C Expression in Pediatric Brainstem Glioma to be presented at the  4th Biennial Society for Neuro-Oncology Pediatric Neuro-Oncology Basic and Translational Research Conference

Dr. Saratsis was invited to present her research in the 2017 DIPG Symposium, hosted by the DIPG Collaborative

Dr. Saratsis presented her work examining the role of Tenascin-C expression in DIPG at the 84th Annual Meeting of the American Association of Neurological Surgeons and the 2016 Association for Clinical and Translational Science Annual Meeting

Dr. Saratsis presented her work characterizing Histone H3 Post-Translational Modifications using Paraffin-Embedded Pediatric Glioma Tissue Samples at the American Neurological Association’s 2016 Annual Meeting, the 2016 Annual Scientific Meeting of the Society for Neuro-Oncology, and the 2016 Annual Meeting of the AANS/CNS Section on Pediatric Neurological Surgery

Dr. Saratsis presented her work to detect Histone H3 mutations in pediatric glioma via tumor DNA derived from cerebrospinal fluid at the 2016 Annual Scientific Meeting of the Society for Neuro-Oncology, the 2016 Annual Meeting of the AANS/CNS Section on Pediatric Neurological Surgery

Dr. Saratsis and colleagues from Children’s National Medical Center presented their collaborative project to characterize in vivo and in vitro models of DIPG at the 2016 International Society for Pediatric Neuro-Oncology Scientific Meeting in Liverpool, England

Dr. Saratsis serves as a Co-Investigator with Dr. Irina Balyasnikova and Dr. Rintaro Hashizume on their project, Developing a Non-Invasive Stem Cell-Based Approach to Treatment of Pediatric Brainstem Glioma, the recipients of a 2016 IDP Foundation Challenge Award

Amanda Saratsis, MD is part of a collaborative research team that has found a molecule that stops the growth of an aggressive pediatric brain tumor. Their findings are featured in stories from Northwestern Medicine and Lurie Children’s Hospital. Nature Medicine has an advanced online publication of their research

Watch Amanda Saratsis, MD in this Northwestern Brain Tumor Institute video highlighting patient care and cancer research

Amanda Saratsis, MD awarded an NIH K08 Mentored Clinical Scientist Award, entitled ‘Investigation of Histone H3 post-translational modifications in pediatric brainstem glioma’

Amanda Saratsis, MD, Rintaro Hashizume, MD/PhD, and C. David James, PhD, and others are featured as part of an interdisciplinary team of physicians and researchers combating pediatric brain tumors in Lurie’s Heroes Spring 2016 issue

Amanda Saratsis, MD researches pediatric brain tumors with help from NUCATS

Amanda Saratsis, MD featured in January issue 'Origins' of Northwestern Research News 

Rintaro Hashizume, MD/PhD, Amanda Saratsis, MD, and C. David James, PhD part of pediatric brain tumor ‘Dream Team’

Amanda Saratsis, MD presents her research at the 2015 Children’s Ball for the Children’s Research Fund

Department of Neurological Surgery faculty Amanda Saratsis, MD, Rintaro Hashizume, MD/PhD, and David James, PhD awarded large gift from the John McNicholas Pediatric Brain Tumor Foundation

Amanda Saratsis, MD featured in Research News of Lurie Children’s Hospital ‘In Touch

Amanda Saratsis, MD, named NUCATS KL2 scholar awardee for research of histone modifications in pediatric brainstem glioma.

Dr. Saratsis was invited to compete against other researchers for the Cure Snap Grant Award at the 2015 DIPG Collaborative Symposium, where her project, “Preclinical Investigation of Tenascin-C as a Novel Therapeutic Target for DIPG,” was selected for funding from The Cure Starts Now Foundation

Dr. Saratsis was selected as the inaugural Bagan Family Fellow and recipient of a Young Clinician Investigator Award by the Neurosurgery Research & Education Foundation at the 83rd Annual Scientific Meeting of the American Association of Neurological Surgeons in Washington, DC.

Dr. Saratsis was honored with the Top Poster Award (Basic Science) on December 5 at the at the 43rd Annual Scientific Meeting of the AANS/CNS Section on Pediatric Neurologic Surgery for The Role of Tenascin-C Expression in Pediatric Brainstem Glioma

Dr. Saratsis was invited to present her work characterizing pediatric brainstem glioma tissue in the Lurie Children’s Hospital Department of Pathology Grand Rounds in September, 2015

    Selected Publications

    Huang TY, Piunti A, Lulla R, Qi J, Horbinski CM, Tomita T, James CD, Shilatifard A, Saratsis AM. Detection of Histone H3 Mutations in Cerebrospinal Fluid-Derived Tumor DNA from Children with Diffuse Midline Glioma. Acta Neuropathol Commun. Acta Neuropathol Commun. 2017 Apr 17;5(1):28. PMID: 28416018

    Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q, Takahashi YH, Woodfin AR, Misharin AV, Abshiru NA, Lulla RR, Saratsis AM2, Kelleher NL, James CD, Shilatifard A. Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas. Nat Med. 2017 Feb 27. doi: 10.1038/nm.4296. [Epub ahead of print]

    Lulla R, Saratsis AM, Hashizume R. Mutations in chromatin machinery and pediatric high-grade glioma. Science Advances 18 Mar 2016: e1501354.

    Yadavilli S, Scafidi J, Becher O, Saratsis AM, Hiner RL, Kambhampati M, Mariarita S, MacDonald TJ, Codispoti K, Magge SN,  Jaiswal JK, Packer RJ,  Nazarian J. The Emerging Role of NG2 in Pediatric Diffuse Intrinsic Pontine Glioma. Oncotarget. Accepted 2015 March 11. Online ISSN: 1949-2553

    Kambhampati M, Perez JP, Yadavilli S, Saratsis AM, Hill AD, Ho CY, Panditharatna E, Markel M, Packer RJ, Nazarian J. A standardized autopsy procurement allows for the comprehensive study of DIPG biology. Oncotarget. 2015 Jan 24. PMID: 25749048  

    Saratsis AM, Kambhampati M, Snyder K, Yadavilli S, Devaney JM, Harmon B, Hall J, Raabe EH, An P, Weingart M, Rood BR, Magge SN, MacDonald TJ, Packer RJ, Nazarian J. Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes. Acta Neuropathol. 2014 Jun;127(6):881-95. PMID: 24297113

    Saratsis AM, Yadavilli S, Magge S, Rood BR, Perez J, Hill DA, Hwang E, Kilburn L, Packer RJ, Nazarian J. Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid. Neuro Oncol. 2012 May;14(5):547-60. PMID: 22492959

    Amanda Muhs Saratsis, MD

    Amanda Muhs Saratsis, MD
    Assistant Professor in Neurological Surgery

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