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Northwestern University Feinberg School of Medicine
Mojgan Naghavi Lab

Publications

Learn more about the work that we do in the Mojgan Naghavi Laboratory through our recent publications.

  1. Gu F, Boisjoli M, Naghavi MH  HIV-1 promotes ubiquitination of the amyloidogenic C-terminal fragment of APP to support viral replication.  Nat Commun  2023 Jul 15;14(1):4227. pii:4227
  2. Malikov V, Naghavi MH  FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently Regulating Capsid Transport and Host Interferon-Stimulated Gene Expression.  J Virol  2023 Jun 29;97(6):e0049923. pii:e00499-23
  3. Naghavi MH  Virus update for the M2 "mac-in-touch".  J Cell Biol  2023 May 01;222(5). pii:e202303016
  4. Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B  et al.  Virology under the Microscope-a Call for Rational Discourse.  mSphere  2023 Apr 20;8(2):e0003423. pii:e00034-23
  5. Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B  et al.  Virology under the Microscope-a Call for Rational Discourse.  mBio  2023 Feb 28;14(1):e0018823. pii:e00188-23
  6. Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B  et al.  Virology under the Microscope-a Call for Rational Discourse.  J Virol  2023 Feb 28;97(2):e0008923. pii:e00089-23
  7. da Silva ES, Naghavi MH  Microtubules and viral infection.  Adv Virus Res  2023;115:87-134. doi:10.1016/bs.aivir.2023.02.003
  8. Stephens C, Naghavi MH  The host cytoskeleton: a key regulator of early HIV-1 infection.  FEBS J  2022 Dec 16;. doi:10.1111/febs.16706
  9. Malikov V, Meade N, Simons LM, Hultquist JF, Naghavi MH  FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression.  Cell Rep  2022 Feb 15;38(7):110396. doi:10.1016/j.celrep.2022.110396
  10. Shanmugapriya S, Santos da Silva E, Campbell JA, Boisjoli MP, Naghavi MH  Dynactin 1 negatively regulates HIV-1 infection by sequestering the host cofactor CLIP170.  Proc Natl Acad Sci U S A  2021 Oct 26;118(43). pii:e2102884118
  11. Naghavi MH  HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection.  Retrovirology  2021 Jul 06;18(1):19. pii:19
  12. Santos da Silva E, Shanmugapriya S, Malikov V, Gu F, Delaney MK, Naghavi MH  HIV-1 capsids mimic a microtubule regulator to coordinate early stages of infection.  EMBO J  2020 Oct 15;39(20):e104870. pii:e104870
  13. Mitra S, Shanmugapriya S, Santos da Silva E, Naghavi MH  HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus.  J Virol  2020 Jul 01;94(14). pii:e00404-20
  14. Huang PT, Summers BJ, Xu C, Perilla JR, Malikov V, Naghavi MH, Xiong Y  FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.  Cell Rep  2019 Aug 27;28(9):2373-2385.e7. doi:10.1016/j.celrep.2019.07.079
  15. Walsh D, Naghavi MH  Exploitation of Cytoskeletal Networks during Early Viral Infection.  Trends Microbiol  2019 Jan;27(1):39-50. doi:10.1016/j.tim.2018.06.008
  16. Naghavi MH  "APP"reciating the complexity of HIV-induced neurodegenerative diseases.  PLoS Pathog  2018 Oct;14(10):e1007309. pii:e1007309
  17. Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D  Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.  Cell  2018 Aug 23;174(5):1143-1157.e17. doi:10.1016/j.cell.2018.06.053
  18. Chai Q, Jovasevic V, Malikov V, Sabo Y, Morham S, Walsh D, Naghavi MH  Author Correction: HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration.  Nat Commun  2018 Jun 05;9(1):2257. pii:2257
  19. Chai Q, Jovasevic V, Malikov V, Sabo Y, Morham S, Walsh D, Naghavi MH  HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration.  Nat Commun  2017 Nov 15;8(1):1522. pii:1522
  20. Malikov V, Naghavi MH  Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating.  Cell Rep  2017 Sep 19;20(12):2792-2799. doi:10.1016/j.celrep.2017.08.076
  21. Delaney MK, Malikov V, Chai Q, Zhao G, Naghavi MH  Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport.  Proc Natl Acad Sci U S A  2017 Aug 15;114(33):E6932-E6941. doi:10.1073/pnas.1700247114
  22. Naghavi MH, Walsh D  Microtubule Regulation and Function during Virus Infection.  J Virol  2017 Aug 15;91(16). pii:e00538-17
  23. Jovasevic V, Naghavi MH, Walsh D  Microtubule plus end-associated CLIP-170 initiates HSV-1 retrograde transport in primary human cells.  J Cell Biol  2015 Oct 26;211(2):323-37. doi:10.1083/jcb.201505123
  24. Malikov V, da Silva ES, Jovasevic V, Bennett G, de Souza Aranha Vieira DA, Schulte B, Diaz-Griffero F, Walsh D, Naghavi MH  HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.  Nat Commun  2015 Mar 30;6:6660. doi:10.1038/ncomms7660
  25. Naghavi MH  Stable microtubule subsets facilitate early HIV-1 infection.  AIDS Res Hum Retroviruses  2014 Mar;30(3):211-2. doi:10.1089/aid.2014.0026
  26. Sabo Y, Walsh D, Barry DS, Tinaztepe S, de Los Santos K, Goff SP, Gundersen GG, Naghavi MH  HIV-1 induces the formation of stable microtubules to enhance early infection.  Cell Host Microbe  2013 Nov 13;14(5):535-46. doi:10.1016/j.chom.2013.10.012
  27. Naghavi MH, Gundersen GG, Walsh D  Plus-end tracking proteins, CLASPs, and a viral Akt mimic regulate herpesvirus-induced stable microtubule formation and virus spread.  Proc Natl Acad Sci U S A  2013 Nov 05;110(45):18268-73. doi:10.1073/pnas.1310760110
  28. Naghavi M, Walsh D  Research funding: Learn from Ireland's knowledge economy.  Nature  2011 Aug 24;476(7361):399. doi:10.1038/476399b
  29. Brown C, Morham SG, Walsh D, Naghavi MH  Focal adhesion proteins talin-1 and vinculin negatively affect paxillin phosphorylation and limit retroviral infection.  J Mol Biol  2011 Jul 29;410(5):761-77. doi:10.1016/j.jmb.2011.03.076
  30. Henning MS, Stiedl P, Barry DS, McMahon R, Morham SG, Walsh D, Naghavi MH  PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1.  Virology  2011 Jul 05;415(2):114-21. doi:10.1016/j.virol.2011.04.006
  31. Henning MS, Morham SG, Goff SP, Naghavi MH  PDZD8 is a novel Gag-interacting factor that promotes retroviral infection.  J Virol  2010 Sep;84(17):8990-5. doi:10.1128/JVI.00843-10
  32. Haedicke J, Brown C, Naghavi MH  The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection.  Proc Natl Acad Sci U S A  2009 Aug 18;106(33):14040-5. doi:10.1073/pnas.0900502106
  33. Haedicke J, de Los Santos K, Goff SP, Naghavi MH  The Ezrin-radixin-moesin family member ezrin regulates stable microtubule formation and retroviral infection.  J Virol  2008 May;82(9):4665-70. doi:10.1128/JVI.02403-07
  34. Naghavi MH, Goff SP  Retroviral proteins that interact with the host cell cytoskeleton.  Curr Opin Immunol  2007 Aug;19(4):402-7
  35. Naghavi MH, Valente S, Hatziioannou T, de Los Santos K, Wen Y, Mott C, Gundersen GG, Goff SP  Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells.  EMBO J  2007 Jan 10;26(1):41-52
  36. Naghavi MH, Hatziioannou T, Gao G, Goff SP  Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells.  Genes Dev  2005 May 01;19(9):1105-15
  37. Lemieux AM, Paré ME, Audet B, Legault E, Lefort S, Boucher N, Landry S, van Opijnen T, Berkhout B, Naghavi MH  et al.  T-cell activation leads to poor activation of the HIV-1 clade E long terminal repeat and weak association of nuclear factor-kappaB and NFAT with its enhancer region.  J Biol Chem  2004 Dec 17;279(51):52949-60
  38. Naghavi MH, Nowak P, Andersson J, Sönnerborg A, Yang H, Tracey KJ, Vahlne A  Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner.  Virology  2003 Sep 15;314(1):179-89
  39. Estable MC, Naghavi MH, Kato H, Xiao H, Qin J, Vahlne A, Roeder RG  MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.  J Biomed Sci  2002;9(3):234-45
  40. Naghavi MH, Estable MC, Schwartz S, Roeder RG, Vahlne A  Upstream stimulating factor affects human immunodeficiency virus type 1 (HIV-1) long terminal repeat-directed transcription in a cell-specific manner, independently of the HIV-1 subtype and the core-negative regulatory element.  J Gen Virol  2001 Mar;82(Pt 3):547-559. doi:10.1099/0022-1317-82-3-547
  41. Su J, Naghavi MH, Jejcic A, Horal P, Furuta Y, Wu YP, Li SL, Hall WW, Goobar-Larsson L, Svennerholm B  et al.  The tripeptide glycyl-prolyl-glycine amide does not affect the early steps of the human immunodeficiency virus type 1 replication.  J Hum Virol  2001;4(1):8-15
  42. Su J, Andersson E, Horal P, Naghavi MH, Palm A, Wu YP, Eriksson K, Jansson M, Wigzell H, Svennerholm B  et al.  The nontoxic tripeptide glycyl-prolyl-glycine amide inhibits the replication of human immunodeficiency virus type 1.  J Hum Virol  2001;4(1):1-7
  43. Naghavi MH, Schwartz S, Sönnerborg A, Vahlne A  Long terminal repeat promoter/enhancer activity of different subtypes of HIV type 1.  AIDS Res Hum Retroviruses  1999 Sep 20;15(14):1293-303
  44. Naghavi MH, Salminen MO, Sönnerborg A, Vahlne A  DNA sequence of the long terminal repeat of human immunodeficiency virus type 1 subtype A through G.  AIDS Res Hum Retroviruses  1999 Mar 20;15(5):485-8
  45. Allander T, Gruber A, Naghavi M, Beyene A, Söderström T, Björkholm M, Grillner L, Persson MA  Frequent patient-to-patient transmission of hepatitis C virus in a haematology ward.  Lancet  1995 Mar 11;345(8950):603-7