Northwestern University Feinberg School of Medicine

Evangelos Kiskinis Lab

Publications

*designates equal first authorship

2017

Santos DP, Kiskinis E. Generation of Spinal Motor Neurons from Human Pluripotent Stem Cells.Methods Mol Biol. 2017;1538:53-66. PMID: 27943183

2016

Santos DP, Kiskinis E, Eggan K, Merkle FT. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2016 Aug17;38:5B.6.1-5B.6.60. PMID: 27532820

2015

Ichida JK, Kiskinis E. Probing disorders of the nervous system using reprogramming approaches. EMBO J. 2015 Apr 29. pii: e201591267. [Epub ahead of print] Review. PMID: 25925386

Schwarz-Romond T, Kiskinis E, Eggan K. Focus on induced pluripotency and cellular reprogramming. EMBO J. 2015 Apr 27. pii: e201591615. [Epub ahead of print] No abstract available. PMID: 25916828

2014

de Boer AS, Koszka K, Kiskinis E, Suzuki N, Davis-Dusenbery BN, Eggan K. Genetic validation of a therapeutic target in a mouse model of ALS. Sci Transl Med. 2014 Aug 6;6(248):248ra104. doi: 10.1126/scitranslmed.3009351. PMID: 25100738

Kiskinis E*, Sandoe J*, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014 Jun 5;14(6):781-95. doi: 10.1016/j.stem.2014.03.004. Epub 2014 Apr 3. PMID: 24704492

Wainger BJ*, Kiskinis E*, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014 Apr 10;7(1):1-11. doi: 10.1016/j.celrep.2014.03.019. Epub 2014 Apr 3. PMID: 24703839

Alami NH*, Smith RB*, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutationsNeuron. 2014 Feb 5;81(3):536-43. doi: 10.1016/j.neuron.2013.12.018. PMID: 24507191

Kiskinis E, Chatzeli L, Curry E, Kaforou M, Frontini A, Cinti S, Montana G, Parker MG, Christian M. RIP140 represses the "brown-in-white" adipocyte program including a futile cycle of triacylglycerol breakdown and synthesis. Mol Endocrinol. 2014 Mar;28(3):344-56. doi: 10.1210/me.2013-1254. Epub 2014 Jan 30. PMID: 24479876

2012

Mekhoubad S, Bock C, de Boer AS, Kiskinis E, Meissner A, Eggan K. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell. 2012 May 4;10(5):595-609. doi: 10.1016/j.stem.2012.02.014. PMID: 22560080

2011

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805. PMID: 21368825

Bock C*, Kiskinis E*, Verstappen G*, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K, Meissner A. Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell linesCell. 2011 Feb 4;144(3):439-52. doi: 10.1016/j.cell.2010.12.032. PMID: 21295703

Boulting GL*, Kiskinis E*, Croft GF*, Amoroso MW*, Oakley DH*, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K. A functionally characterized test set of human induced pluripotent stem cellsNat Biotechnol. 2011 Mar;29(3):279-86. doi: 10.1038/nbt.1783. Epub 2011 Feb 3. PMID: 21293464

2010

Ichida JK, Kiskinis E, Eggan K. Shushing down the epigenetic landscape towards stem cell differentiation.Development. 2010 Aug 1;137(15):2455-60. doi: 10.1242/dev.049130. Epub 2010 Jun 16. PMID: 20554719

Kiskinis E, Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest. 2010 Jan;120(1):51-9. doi: 10.1172/JCI40553. Review. PMID: 20051636

2008

Hallberg M, Morganstein DL, Kiskinis E, Shah K, Kralli A, Dilworth SM, White R, Parker MG, Christian M. A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEAMol Cell Biol. 2008 Nov;28(22):6785-95. doi: 10.1128/MCB.00504-08. Epub 2008 Sep 15. PMID: 18794372

2007

Kiskinis E, Hallberg M, Christian M, Olofsson M, Dilworth SM, White R, Parker MG. RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytesEMBO J. 2007 Nov 28;26(23):4831-40. Epub 2007 Nov 1. PMID: 17972916

2006

García-Pedrero JM, Kiskinis E, Parker MG, Belandia B. The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells.  J Biol Chem. 2006 Aug 11;281(32):22656-64. Epub 2006 Jun 12. PMID: 16769725

Kiskinis E, García-Pedrero JM, Villaronga MA, Parker MG, Belandia B. Identification of BAF57 mutations in human breast cancer cell lines. Breast Cancer Res Treat. 2006 Jul;98(2):191-8. Epub 2006 Mar 15. PMID: 16538531

Powelka AM, Seth A, Virbasius JV, Kiskinis E, Nicoloro SM, Guilherme A, Tang X, Straubhaar J, Cherniack AD, Parker MG, Czech MP. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest. 2006 Jan;116(1):125-36. Epub 2005 Dec 22. PMID: 16374519

2005

Christian M, Kiskinis E, Debevec D, Leonardsson G, White R, Parker MG. RIP140-targeted repression of gene expression in adipocytes.  Mol Cell Biol. 2005 Nov;25(21):9383-91. PMID: 16227589

2002

Kiskinis E, Suter W, Hartmann A. High throughput Comet assay using 96-well plates. Mutagenesis. 2002 Jan;17(1):37-43. PMID: 11752232

2001

Hartmann A, Kiskinis E, Fjällman A, Suter W. Influence of cytotoxicity and compound precipitation on test results in the alkaline comet assayMutat Res. 2001 Oct 18;497(1-2):199-212. PMID: 11525923

Hartmann A, Elhajouji A, Kiskinis E, Poetter F, Martus H, Fjällman A, Frieauff W, Suter W. Use of the alkaline comet assay for industrial genotoxicity screening: comparative investigation with the micronucleus test. Food Chem Toxicol. 2001 Aug;39(8):843-58. PMID: 11434992

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