Northwestern University Feinberg School of Medicine

Evangelos Kiskinis Lab

About Our Lab

Our research program is focused on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of disease. We have two clinical interests, motor neuron disease and epileptic channelopathies. We utilize patient-specific induced pluripotent stem cells (iPSCs) and direct reprogramming methods to generate different neuronal subtypes implicated in these diseases. We then study these cells by a combination of genomic approaches and functional physiological assays. Our hope is that these disease model systems will help us identify points of effective and targeted therapeutic intervention. Find news and more information about our lab.

Selected Publications

Generation of Spinal Motor Neurons from Human Pluripotent Stem Cells.Methods Mol Biol. 2017;1538:53-66. Santos DP, Kiskinis PMID: 27943183

Pathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1.Cell Stem Cell, 2014 Jun 5;14(6):781-95. Kiskinis E*, Sandoe J*, Boulting G, Williams LA, Wainger BJ, Mikkilineni S, Merkle F, Han S, Peng T, Ziller M, Oakley DH, Ichida J, Dicostanza S, Atwater N, Maeder ML, Goodwin MJ, Joung K, Woolf CJ, Brown RH, Eggan K. PMID: 24704492

Reference Maps Of Human ES And iPS Cell Variation Enable High-Throughput Characterization Of Pluripotent Cell Lines.Cell. 2011 Feb 4;144(3):439-52. Bock C*, Kiskinis E*, Verstappen G*, Gu H, Boulting G, Smith ZD, Ziller M, Grinke A, Croft GF, Weygandt-Amoroso M, Oakley DH, Eggan K, Meissner A. PMID: 21295703

Evangelos Kiskinis, PhD

Evangelos Kiskinis, PhD
Assistant Professor in Neurology—Ken and Ruth Davee Department and Physiology

For more information, click here to visit our department page.

For ALS Patients

Clinical Trials
The Northeast ALS Consortium (NEALS) is an independent consortium of researchers who conduct clinical research in motor neuron diseases. Find information on clinical trials for ALS

ALS Clinic
The Lois Insolia ALS Clinic at the Les Turner ALS Research and Patient Center is dedicated to the total care and support of people with ALS, their families and caregivers.