About Our Lab
The Kim Laboratory is interested in elucidating mechanisms of hormone action in reproductive tissues and its diseases. We are interested in the role of abnormally activated AKT pathway in endometrial cancer, endometriosis and uterine fibroids, and how this signaling pathway influences hormone receptor action, specifically, progesterone receptor (PR). We use novel in vitro and in vivo models in our studies, including 3D organ cultures linked together in a microfluidic platform, patient derived xenografted tumors in mice, and conditional Pten null mice. Preclinical studies include testing of AKT inhibitors as well as selective progesterone receptor modulators in various disease contexts. Ongoing collaborative projects include those with the Hope Lab look at hormonal regulation of the endocervix that participate in HIV transmission in women, and with the Khan lab, looking at molecular mechanisms of progesterone receptor modulators for prevention of breast cancer.
- September, 2012
Dr. Julie Kim has been appointed the Susy Y. Hung Associate Professor at Northwestern University.
- September, 2012
Dr. Mario Pineda and Dr. Julie Kim are awarded the Friends of Prentice Grant to study the role of Myeloid Suppressor Cells in recurrent Endometrial Cancer.
- April 2012
IGP student Beth Sefton in the Kim Lab receives award at the 32nd CRS minisymposium for her oral presentation on leiomyomas, AKT and autophagy. Congratulations!
- January 2012
IGP student Irene Lee in the Kim Lab is awarded the Malkin Scholar Award.
Eaton JL, Unno K, Caraveo M, Lu Z, Kim JJ. Increased AKT or MEK1/2 activity influences Progesterone Receptor levels and localization in endometriosis. J Cell Endocrinol Metab 2013 Sep 24. [Epub ahead of print]
Ono M, Yin P, Navarro A, Moravek MB, Coon V JS, Druschitz SA, Serna, Qiang W, Brooks DC, Malpani SS, Ma J, Ercana CM, Mittal N, Monsivaisa D, Dyson MT, Yemelyanov A, Maruyama T, Chakravarti D, Kim JJ, Kurita T, Gottardi CJ, and Bulun SB. WNT/β-Catenin Paracrine Signaling Between Leiomyoma Stem Cells and the Mature Cell Population in Uterine Leiomyoma Cell Growth. Proc Natl Acad Sci U S A. 2013: 110(42):17053-8.
Full a larger list of selected publications visit our publications page.