About Our Lab
Research in the lab examines the neural and computational principles of reward-guided behavior, with a focus on odor-guided behavior. We study brain systems involved in reward processing, learning, generalization, and decision-making such as the striatum and the orbitofrontal cortex. For this, we use a combination of human olfactory psychophysics, computational modeling, fMRI and advanced multivariate analyses techniques borrowed from machine learning. This research may pave the way for understanding decision-making deficits in neurological diseases and addiction, and should ultimately lead to novel diagnostic markers and treatment strategies for these disorders.
Howard JD, Gottfried JA, Tobler PN, Kahnt T. Identity-specific coding of future rewards in the human orbitofrontal cortex. Proc Natl Acad Sci USA 2015, 112(16):5195-200. PMID: 25848032
Kahnt T, Weber S, Hacker H, Robbins TW, Tobler PN. Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans. Journal of Neuroscience 2015 Mar 4; 35(9):4104-11. PMID: 24639493
Kahnt T, Park SQ, Haynes JD, Tobler PN. 2014. Disentangling neural representations of value and salience in the human brain. Proc Natl Acad Sci USA, 111(13):5000-5. PMID: 24639493
News & Events
Our work in the news: Food odors are more enticing to sleep-deprived brains (ScienceNews.org, April 2, 2017)
New paper: Howard JD, Kahnt T. Identity-Specific Reward Representations in Orbitofrontal Cortex Are Modulated by Selective Devaluation. J Neurosci. 2017 Mar 8;37(10):2627-2638.
New grant: Our NIH/NIDCD R01 grant application Principles of olfactory reward processing in the human brain (R01DC015426) was funded.
New grant: Our NIH/NIDA R03 grant application Neural mechanisms of context-dependent stimulus generalization in humans (R03DA040668) was funded.