About Our Lab
Research in the lab examines the neural and computational principles of reward-guided behavior, with a focus on odor-guided behavior. We study brain systems involved in reward processing, learning, generalization, and decision-making such as the striatum and the orbitofrontal cortex. For this, we use a combination of human olfactory psychophysics, computational modeling, fMRI and advanced multivariate analyses techniques borrowed from machine learning. This research may pave the way for understanding decision-making deficits in neurological diseases and addiction, and should ultimately lead to novel diagnostic markers and treatment strategies for these disorders.
Howard JD, Gottfried JA, Tobler PN, Kahnt T. Identity-specific coding of future rewards in the human orbitofrontal cortex. Proc Natl Acad Sci USA 2015, 112(16):5195-200. PMID: 25848032
Kahnt T, Weber S, Hacker H, Robbins TW, Tobler PN. Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans. Journal of Neuroscience 2015 Mar 4; 35(9):4104-11. PMID: 24639493
Kahnt T, Park SQ, Haynes JD, Tobler PN. 2014. Disentangling neural representations of value and salience in the human brain. Proc Natl Acad Sci USA, 111(13):5000-5. PMID: 24639493
News & Events
New paper: Kahnt T, Tobler PN. 2016. Dopamine regulates stimulus generalization in the human hippocampus. eLife;5:e12678
New grant: Our NIH/NIDCD R01 grant application Principles of olfactory reward processing in the human brain (R01DC015426) was funded.
New grant: Our NIH/NIDA R03 grant application Neural mechanisms of context-dependent stimulus generalization in humans (R03DA040668) was funded.
CNS 2017 Annual Meeting
March 25-28, 2016 in San Francisco, California. Attend our symposium Cognitive maps in the orbitofrontal cortex for goal-directed behavior