C. David James, PhD is part of a collaborative research team that has found a molecule that stops the growth of an aggressive pediatric brain tumor. Their findings are featured in the Northwestern Medicine News, and Nature Medicine has an advanced online publication of their research.
Amanda Saratsis, MD, Rintaro Hashizume, MD/PhD, and C. David James, PhD, and others are featured as part of an interdisciplinary team of physicians and researchers combating pediatric brain tumors in Lurie’s Heroes Spring 2016 issue
C. David James, PhD awarded R01 grant for ‘Radiation + Temozolomide Induced Mutation and Malignant Progression of Glioblastoma’
In newly diagnosed glioblastoma (GBM), the common method of treatment is surgical debulking of tumor followed by radiation therapy (RT) and chemotherapy with the DNA alkylator temozolomide (TMZ). The average patient survival with this method is 15 months, during which time the tumor recurs, and no treatment has been identified that increases patient longevity with the recurrent tumor.
A central hypothesis associated with the studies proposed for this grant is that RT + TMZ therapy causes mutations in GBM, and that improved treatment of recurrent GBM requires a detailed understanding of these mutations. The research associated with this proposal will generate, characterize, and validate recurrent RT modified, TMZ modified, and RT + TMZ modified GBM tumor models that can be used by the PI and others interested in the study and treatment of recurrent GBM.
C. David James, PhD appointed Associate Editor of ‘Science Advances’, the recently launched journal from the American Association for the Advancement of Science. ‘Science Advances’ is the first and only open access journal of the AAAS.
Department of Neurological Surgery faculty Amanda Saratsis, MD, Rintaro Hashizume, MD/PhD, and C. David James, PhD awarded large gift from the John McNicholas Pediatric Brain Tumor Foundation
Participating faculty at Cold Spring Harbor Course on Brain Tumors, Cold Spring Harbor, NY, August 2014
Chair, Conference Organizing Committee, 20th International Course on Brain Tumor Research and Therapy, Lake Tahoe, CA, July 2014
Invited lecture, Department of Pathology, Johns Hopkins Medical School, February 2014: "Preclinical testing of experimental therapeutics for treating brain tumors: raising the bar for clinical trial evaluation".