About Our Lab
The research activities of my laboratory are directed towards elucidating the molecular and biological consequences of specific gene alterations in CNS cancer, with particular emphasis on malignant glioma, the most common type of primary CNS tumor, and towards identifying actionable/druggable molecular characteristics of these tumors.
Amanda Saratsis, MD, Rintaro Hashizume, MD/PhD, and C. David James, PhD, and others are featured as part of an interdisciplinary team of physicians and researchers combating pediatric brain tumors in Lurie’s Heroes Spring 2016 issue
C. David James, PhD appointed Associate Editor of ‘Science Advances’, the recently launched journal from the American Association for the Advancement of Science. ‘Science Advances’ is the first and only open access journal of the AAAS.
Department of Neurological Surgery faculty Amanda Saratsis, MD, Rintaro Hashizume, MD/PhD, and C. David James, PhD awarded large gift from the John McNicholas Pediatric Brain Tumor Foundation
Northwestern Brain Tumor Institute Special Guest Lecture: Duane Mitchell, MD/PhD, "Cellular Immunotherapy Targeting Pediatric and Adult Brain Tumors" – Friday, October 24, 2014
Dr. James is invited to lecture at the Josephine Ford Cancer Institute Translational Research Symposium, Henry Ford Hospital, Detroit, MI, December, 2014
Nathanson DA, Gini B, Mottahedeh J, Visnyeis K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao N, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, and Mischel PS. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 343:72-6, 2014. PubMed PMID: 24310612
Mueller S, Hashizume R, Yang X, Kolkowitz I, Olow AK, Phillips J, Smirnov I, Tom MW, Prados MD, James CD, Berger MS, Gupta N, and Haas-Kogan DA. Targeting Wee1 for the treatment of pediatric high-grade gliomas. Neuro-Oncology. 16: 352-360, 2014. PubMed PMID: 24305702