.: Cell & Molecular Biology of HIV :.
I have been a postdoctoral researcher at Northwestern University since 2009. I initially conducted research in HPV infections that cause cervical cancer. In 2013 I joined Dr. Thomas Hope’s laboratory to expand my expertise in infectious diseases and to engage in HIV translational research. It has been a great fulfillment to bridge basic research with (pre)clinical investigations aiming to improve global health through disease prevention.
Preventing sexual HIV transmission by drug delivery systems in the female reproductive tract
Projects, Experiments & Collaborations
My research focuses on acquisition of SHIV viruses in the female reproductive tract of primates treated with a new antiviral drug delivery system. In collaboration with Dr. Patrick F. Kiser’s research group we are examining TDF IVR devices in vivo, and are trying to determine efficacy of drug delivery technology to prevent viral transmission. I am also contributing to a hormonal study in macaque models where we are trying to understand how the menstrual cycle and the presence of hormonal contraceptives in female primates affect SHIV transmission.
- Human papillomavirus E5 oncoproteins bind the A4 endoplasmic reticulum protein to regulate proliferative ability upon differentiation. Kotnik Halavaty K, Regan J, Mehta K, Laimins L. Virology. 2014 Mar;452-453:223-30.
- Oral administration of angiotensin-(1-7) ameliorates type 2 diabetes in rats. Santos SH, Giani JF, Burghi V, Miquet JG, Qadri F, Braga JF, Todiras M, Kotnik K, Alenina N, Dominici FP, Santos RA, Bader M. J Mol Med (Berl). 2014 Mar;92(3):255-65.
- Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. Kotnik K, Popova E, Todiras M, Mori MA, Alenina N, Seibler J, Bader M. PLoS One. 2009;4(4):e5124.
- Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. Morecroft I, Dempsie Y, Bader M, Walther DJ, Kotnik K, Loughlin L, Nilsen M, MacLean MR. Hypertension. 2007 Jan;49(1):232-6.