Northwestern University Feinberg School of Medicine

Kathleen Green Lab

Publications

Learn more about the work that we do in the Green laboratory through our recent publications.

  1. Kam CY, Dubash AD, Magistrati E, Polo S, Satchell KJF, Sheikh F, Lampe PD, Green KJ  Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.  J Cell Biol  2018 Jun 29;. pii:jcb.201710161
  2. Mohamad J, Sarig O, Godsel LM, Peled A, Malchin N, Bochner R, Vodo D, Rabinowitz T, Pavlovsky M, Taiber S, Fried M, Eskin-Schwartz M, Assi S, Shomron N, Uitto J, Koetsier JL, Bergman R, Green KJ, Sprecher E  Filaggrin 2 Deficiency Results in Abnormal Cell-Cell Adhesion in the Cornified Cell Layers and Causes Peeling Skin Syndrome Type A.  J Invest Dermatol  2018 Aug;138(8):1736-1743. pii:S0022-202X(18)31969-9
  3. Polivka L, Hadj-Rabia S, Bal E, Leclerc-Mercier S, Madrange M, Hamel Y, Bonnet D, Mallet S, Lepidi H, Ovaert C, Barbet P, Dupont C, Neven B, Munnich A, Godsel LM, Campeotto F, Weil R, Laplantine E, Marchetto S, Borg JP, Weis WI, Casanova JL, Puel A, Green KJ, Bodemer C, Smahi A  Epithelial barrier dysfunction in desmoglein-1 deficiency.  J Allergy Clin Immunol  2018 Aug;142(2):702-706.e7. pii:S0091-6749(18)30616-X
  4. Nekrasova O, Harmon RM, Broussard JA, Koetsier JL, Godsel LM, Fitz GN, Gardel ML, Green KJ  Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination.  Nat Commun  2018 03 13;9(1):1053. doi:10.1038/s41467-018-03414-6
  5. Vodo D, O'Toole EA, Malchin N, Lahav A, Adir N, Sarig O, Green KJ, Smith FJD, Sprecher E  Striate palmoplantar keratoderma resulting from a missense mutation in DSG1.  Br J Dermatol  2018 Jan 06;. doi:10.1111/bjd.16320
  6. Broussard JA, Green KJ  Research Techniques Made Simple: Methodology and Applications of Förster Resonance Energy Transfer (FRET) Microscopy.  J Invest Dermatol  2017 Nov;137(11):e185-e191. pii:S0022-202X(17)32952-4
  7. Quinlan RA, Schwarz N, Windoffer R, Richardson C, Hawkins T, Broussard JA, Green KJ, Leube RE  A rim-and-spoke hypothesis to explain the biomechanical roles for cytoplasmic intermediate filament networks.  J Cell Sci  2017 Oct 15;130(20):3437-3445. doi:10.1242/jcs.202168
  8. Rübsam M, Broussard JA, Wickström SA, Nekrasova O, Green KJ, Niessen CM  Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective.  Cold Spring Harb Perspect Biol  2017 Sep 11;. pii:a029207
  9. Najor NA, Fitz GN, Koetsier JL, Godsel LM, Albrecht LV, Harmon R, Green KJ  Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.  Elife  2017 09 11;6. doi:10.7554/eLife.22599
  10. Broussard JA, Yang R, Huang C, Nathamgari SSP, Beese AM, Godsel LM, Hegazy MH, Lee S, Zhou F, Sniadecki NJ, Green KJ, Espinosa HD  The desmoplakin-intermediate filament linkage regulates cell mechanics.  Mol Biol Cell  2017 Nov 07;28(23):3156-3164. doi:10.1091/mbc.E16-07-0520
  11. Eskin-Schwartz M, Drozhdina M, Sarig O, Gat A, Jackman T, Isakov O, Shomron N, Samuelov L, Malchin N, Peled A, Vodo D, Hovnanian A, Ruzicka T, Koshkin S, Harmon RM, Koetsier JL, Green KJ, Paller AS, Sprecher E  Epidermolytic Ichthyosis Sine Epidermolysis.  Am J Dermatopathol  2017 Jun;39(6):440-444. doi:10.1097/DAD.0000000000000674
  12. Jones JC, Kam CY, Harmon RM, Woychek AV, Hopkinson SB, Green KJ  Intermediate Filaments and the Plasma Membrane.  Cold Spring Harb Perspect Biol  2017 Jan 03;9(1). pii:a025866
  13. Samuelov L, Li Q, Bochner R, Najor NA, Albrecht L, Malchin N, Goldsmith T, Grafi-Cohen M, Vodo D, Fainberg G, Meilik B, Goldberg I, Warshauer E, Rogers T, Edie S, Ishida-Yamamoto A, Burzenski L, Erez N, Murray SA, Irvine AD, Shultz L, Green KJ, Uitto J, Sprecher E, Sarig O  SVEP1 plays a crucial role in epidermal differentiation.  Exp Dermatol  2017 05;26(5):423-430. doi:10.1111/exd.13256
  14. Green KJ, Niessen CM  Degrees of Freedom: Your Future in Biomedical Research.  J Invest Dermatol  2016 06;136(6):1073-6. doi:10.1016/j.jid.2016.03.025
  15. Dubash AD, Kam CY, Aguado BA, Patel DM, Delmar M, Shea LD, Green KJ  Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.  J Cell Biol  2016 Feb 15;212(4):425-38. doi:10.1083/jcb.201507018
  16. Arnette C, Koetsier JL, Hoover P, Getsios S, Green KJ  In Vitro Model of the Epidermis: Connecting Protein Function to 3D Structure.  Methods Enzymol  2016;569:287-308. doi:10.1016/bs.mie.2015.07.015
  17. Boyden LM, Kam CY, Hernández-Martín A, Zhou J, Craiglow BG, Sidbury R, Mathes EF, Maguiness SM, Crumrine DA, Williams ML, Hu R, Lifton RP, Elias PM, Green KJ, Choate KA  Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome.  Hum Mol Genet  2016 Jan 15;25(2):348-57. doi:10.1093/hmg/ddv481
  18. McAleer MA, Pohler E, Smith FJ, Wilson NJ, Cole C, MacGowan S, Koetsier JL, Godsel LM, Harmon RM, Gruber R, Crumrine D, Elias PM, McDermott M, Butler K, Broderick A, Sarig O, Sprecher E, Green KJ, McLean WH, Irvine AD  Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin.  J Allergy Clin Immunol  2015 Nov;136(5):1268-76. doi:10.1016/j.jaci.2015.05.002
  19. Sassano A, Mavrommatis E, Arslan AD, Kroczynska B, Beauchamp EM, Khuon S, Chew TL, Green KJ, Munshi HG, Verma AK, Platanias LC  Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells.  Mol Cell Biol  2015 Aug;35(15):2684-98. doi:10.1128/MCB.00019-15
  20. Albrecht LV, Zhang L, Shabanowitz J, Purevjav E, Towbin JA, Hunt DF, Green KJ  GSK3- and PRMT-1-dependent modifications of desmoplakin control desmoplakin-cytoskeleton dynamics.  J Cell Biol  2015 Mar 02;208(5):597-612. doi:10.1083/jcb.201406020
  21. Broussard JA, Getsios S, Green KJ  Desmosome regulation and signaling in disease.  Cell Tissue Res  2015 Jun;360(3):501-12. doi:10.1007/s00441-015-2136-5
  22. Johnson JL, Najor NA, Green KJ  Desmosomes: regulators of cellular signaling and adhesion in epidermal health and disease.  Cold Spring Harb Perspect Med  2014 Nov 03;4(11):a015297. doi:10.1101/cshperspect.a015297
  23. Patel DM, Dubash AD, Kreitzer G, Green KJ  Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions.  J Cell Biol  2014 Sep 15;206(6):779-97. doi:10.1083/jcb.201312110
  24. Todorovic V, Koetsier JL, Godsel LM, Green KJ  Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation.  Mol Biol Cell  2014 Nov 15;25(23):3749-64. doi:10.1091/mbc.E14-05-0968
  25. Patel DM, Green KJ  Desmosomes in the heart: a review of clinical and mechanistic analyses.  Cell Commun Adhes  2014 Jun;21(3):109-28. doi:10.3109/15419061.2014.906533
  26. Lowndes M, Rakshit S, Shafraz O, Borghi N, Harmon RM, Green KJ, Sivasankar S, Nelson WJ  Different roles of cadherins in the assembly and structural integrity of the desmosome complex.  J Cell Sci  2014 May 15;127(Pt 10):2339-50. doi:10.1242/jcs.146316
  27. Johnson JL, Koetsier JL, Sirico A, Agidi AT, Antonini D, Missero C, Green KJ  The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure.  J Invest Dermatol  2014 Aug;134(8):2154-2162. pii:S0022-202X(15)36951-7
  28. Moy I, Todorović V, Dubash AD, Coon JS, Parker JB, Buranapramest M, Huang CC, Zhao H, Green KJ, Bulun SE  Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells.  Oncogene  2015 Jan 15;34(3):323-33. doi:10.1038/onc.2013.553
  29. Harmon RM, Green KJ  Structural and functional diversity of desmosomes.  Cell Commun Adhes  2013 Dec;20(6):171-87. doi:10.3109/15419061.2013.855204
  30. Samuelov L, Sarig O, Harmon RM, Rapaport D, Ishida-Yamamoto A, Isakov O, Koetsier JL, Gat A, Goldberg I, Bergman R, Spiegel R, Eytan O, Geller S, Peleg S, Shomron N, Goh CSM, Wilson NJ, Smith FJD, Pohler E, Simpson MA, McLean WHI, Irvine AD, Horowitz M, McGrath JA, Green KJ, Sprecher E  Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting.  Nat Genet  2013 Oct;45(10):1244-1248. doi:10.1038/ng.2739
  31. Dubash AD, Koetsier JL, Amargo EV, Najor NA, Harmon RM, Green KJ  The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.  J Cell Biol  2013 Aug 19;202(4):653-66. doi:10.1083/jcb.201304133
  32. Nekrasova O, Green KJ  Desmosome assembly and dynamics.  Trends Cell Biol  2013 Nov;23(11):537-46. doi:10.1016/j.tcb.2013.06.004
  33. Koetsier JL, Amargo EV, Todorović V, Green KJ, Godsel LM  Plakophilin 2 affects cell migration by modulating focal adhesion dynamics and integrin protein expression.  J Invest Dermatol  2014 Jan;134(1):112-122. pii:S0022-202X(15)36463-0
  34. Green KJ, Niessen CM, Godsel LM, Kulesz-Martin MF  Montagna Symposium 2012: Keeping it all together--adhesion, the cytoskeleton, and signaling in morphogenesis and tissue function.  J Invest Dermatol  2013 May;133(5):1124-8. doi:10.1038/jid.2013.59
  35. Harmon RM, Simpson CL, Johnson JL, Koetsier JL, Dubash AD, Najor NA, Sarig O, Sprecher E, Green KJ  Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation.  J Clin Invest  2013 Apr;123(4):1556-70. doi:10.1172/JCI65220
View all publications by Dr. Kathleen J. Green listed in the National Library of Medicine (PubMed).