Northwestern University Feinberg School of Medicine

Cara Gottardi Lab

Publications

Learn more about the work that we do in the Gottardi Laboratory through our recent publications.

  1. Sennello JA, Misharin AV, Flozak AS, Berdnikovs S, Cheresh P, Varga J, Kamp DW, Budinger GR, Gottardi CJ, Lam AP  Lrp5/β-catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis.  Am J Respir Cell Mol Biol  2016 Sep 26;
  2. Flozak AS, Lam AP, Gottardi CJ  A Simple Method to Assess Abundance of the β-Catenin Signaling Pool in Cells.  Methods Mol Biol  2016;1481:49-60. doi:10.1007/978-1-4939-6393-5_6
  3. Serebryannyy LA, Parilla M, Annibale P, Cruz CM, Laster K, Gratton E, Kudryashov D, Kosak ST, Gottardi CJ, de Lanerolle P  Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.  J Cell Sci  2016 Sep 15;129(18):3412-25. doi:10.1242/jcs.195867
  4. Folmsbee SS, Wilcox DR, Tyberghein K, De Bleser P, Tourtellotte WG, van Hengel J, van Roy F, Gottardi CJ  αT-catenin in restricted brain cell types and its potential connection to autism.  J Mol Psychiatry  2016;4:2. doi:10.1186/s40303-016-0017-9
  5. Folmsbee SS, Budinger GR, Bryce PJ, Gottardi CJ  The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation.  J Allergy Clin Immunol  2016 Jul;138(1):123-129.e2. doi:10.1016/j.jaci.2015.11.037
  6. Chen Y, Li Y, Xue J, Gong A, Yu G, Zhou A, Lin K, Zhang S, Zhang N, Gottardi CJ, Huang S  Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.  EMBO J  2016 Mar 15;35(6):668-84. doi:10.15252/embj.201592810
  7. Reinke L, Lam AP, Flozak AS, Varga J, Gottardi CJ  Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling.  Biochem Biophys Res Commun  2016 Feb 12;470(3):606-12. doi:10.1016/j.bbrc.2016.01.097
  8. McCrea PD, Gottardi CJ  Beyond β-catenin: prospects for a larger catenin network in the nucleus.  Nat Rev Mol Cell Biol  2016 Jan;17(1):55-64. doi:10.1038/nrm.2015.3
  9. Li J, Newhall J, Ishiyama N, Gottardi C, Ikura M, Leckband DE, Tajkhorshid E  Structural Determinants of the Mechanical Stability of α-Catenin.  J Biol Chem  2015 Jul 31;290(31):18890-903. doi:10.1074/jbc.M115.647941
  10. McCrea PD, Maher MT, Gottardi CJ  Nuclear signaling from cadherin adhesion complexes.  Curr Top Dev Biol  2015;112:129-96. doi:10.1016/bs.ctdb.2014.11.018
  11. Escobar DJ, Desai R, Ishiyama N, Folmsbee SS, Novak MN, Flozak AS, Daugherty RL, Mo R, Nanavati D, Sarpal R, Leckband D, Ikura M, Tepass U, Gottardi CJ  α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.  J Cell Sci  2015 Mar 15;128(6):1150-65. doi:10.1242/jcs.163824
  12. Folmsbee SS, Morales-Nebreda L, Van Hengel J, Tyberghein K, Van Roy F, Budinger GR, Bryce PJ, Gottardi CJ  The cardiac protein αT-catenin contributes to chemical-induced asthma.  Am J Physiol Lung Cell Mol Physiol  2015 Feb 1;308(3):L253-8. doi:10.1152/ajplung.00331.2014
  13. Valenti F, Ibetti J, Komiya Y, Baxter M, Lucchese AM, Derstine L, Covaciu C, Rizzo V, Vento R, Russo G, Macaluso M, Cotelli F, Castiglia D, Gottardi CJ, Habas R, Giordano A, Bellipanni G  The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.  J Cell Biochem  2015 Mar;116(3):418-30. doi:10.1002/jcb.24993
  14. McEwen AE, Maher MT, Mo R, Gottardi CJ  E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion.  Mol Biol Cell  2014 Aug 15;25(16):2365-74. doi:10.1091/mbc.E14-01-0690
  15. Lam AP, Herazo-Maya JD, Sennello JA, Flozak AS, Russell S, Mutlu GM, Budinger GR, DasGupta R, Varga J, Kaminski N, Gottardi CJ  Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.  Am J Respir Crit Care Med  2014 Jul 15;190(2):185-95. doi:10.1164/rccm.201401-0079OC
  16. Daugherty RL, Serebryannyy L, Yemelyanov A, Flozak AS, Yu HJ, Kosak ST, deLanerolle P, Gottardi CJ  α-Catenin is an inhibitor of transcription.  Proc Natl Acad Sci U S A  2014 Apr 8;111(14):5260-5. doi:10.1073/pnas.1308663111
  17. Ono M, Yin P, Navarro A, Moravek MB, Coon V JS, Druschitz SA, Gottardi CJ, Bulun SE  Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth.  Fertil Steril  2014 May;101(5):1441-9. doi:10.1016/j.fertnstert.2014.01.017
  18. Barry AK, Tabdili H, Muhamed I, Wu J, Shashikanth N, Gomez GA, Yap AS, Gottardi CJ, de Rooij J, Wang N, Leckband DE  α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction.  J Cell Sci  2014 Apr 15;127(Pt 8):1779-91. doi:10.1242/jcs.139014
  19. Lam AP, Gottardi CJ  Fat in fibrosis.  Am J Respir Crit Care Med  2013 Nov 15;188(10):1268-9. doi:10.1164/rccm.201305-0971LE
  20. Ono M, Yin P, Navarro A, Moravek MB, Coon JS, Druschitz SA, Serna VA, Qiang W, Brooks DC, Malpani SS, Ma J, Ercan CM, Mittal N, Monsivais D, Dyson MT, Yemelyanov A, Maruyama T, Chakravarti D, Kim JJ, Kurita T, Gottardi CJ, Bulun SE  Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.  Proc Natl Acad Sci U S A  2013 Oct 15;110(42):17053-8. doi:10.1073/pnas.1313650110
  21. Gottardi CJ, Königshoff M  Considerations for targeting β-catenin signaling in fibrosis.  Am J Respir Crit Care Med  2013 Mar 15;187(6):566-8. doi:10.1164/rccm.201301-0144ED
  22. Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, DeBerardinis RJ, Lavker RM, Chandel NS  Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.  Sci Signal  2013 Feb 5;6(261):ra8. doi:10.1126/scisignal.2003638
  23. Campos ML, Sánchez-Arévalo Lobo VJ, Rodolosse A, Gottardi CJ, Mafficini A, Beghelli S, Scardoni M, Bassi C, Scarpa A, Real FX  ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.  Biochem J  2013 May 1;451(3):395-405. doi:10.1042/BJ20120873
  24. McEwen AE, Escobar DE, Gottardi CJ  Signaling from the adherens junction.  Subcell Biochem  2012;60:171-96. doi:10.1007/978-94-007-4186-7_8
  25. Wei J, Fang F, Lam AP, Sargent JL, Hamburg E, Hinchcliff ME, Gottardi CJ, Atit R, Whitfield ML, Varga J  Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.  Arthritis Rheum  2012 Aug;64(8):2734-45. doi:10.1002/art.34424
  26. Jain M, Lam A, Gottardi CJ  Tissue-specific knockout/knockdown of type 2 TGF-β receptor and protection against bleomycin injury/fibrosis.  Am J Respir Crit Care Med  2011 Oct 15;184(8):983; author reply 983-4
  27. Lam AP, Gottardi CJ  β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target.  Curr Opin Rheumatol  2011 Nov;23(6):562-7. doi:10.1097/BOR.0b013e32834b3309
  28. Smith KA, Tong X, Abu-Yousif AO, Mikulec CC, Gottardi CJ, Fischer SM, Pelling JC  UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes.  Mol Carcinog  2012 Sep;51(9):734-45. doi:10.1002/mc.20840
  29. Zhou Q, Pardo A, Königshoff M, Eickelberg O, Budinger GR, Thavarajah K, Gottardi CJ, Jones J, Varga J, Selman M, Sznajder JI, Raj JU, Zhou G  Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis.  FASEB J  2011 Sep;25(9):3032-44. doi:10.1096/fj.10-177824
  30. Mirkovic I, Gault WJ, Rahnama M, Jenny A, Gaengel K, Bessette D, Gottardi CJ, Verheyen EM, Mlodzik M  Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin.  Nat Struct Mol Biol  2011 Jun;18(6):665-72. doi:10.1038/nsmb.2049
  31. Burkhalter RJ, Symowicz J, Hudson LG, Gottardi CJ, Stack MS  Integrin regulation of beta-catenin signaling in ovarian carcinoma.  J Biol Chem  2011 Jul 1;286(26):23467-75. doi:10.1074/jbc.M110.199539
  32. Lam AP, Gottardi CJ, Tuder R  Regenerative pathways and emphysema: a new paradigm?  Am J Respir Crit Care Med  2011 Mar 15;183(6):688-90. doi:10.1164/rccm.201011-1772ED
  33. Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ  Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.  Am J Respir Cell Mol Biol  2011 Nov;45(5):915-22. doi:10.1165/rcmb.2010-0113OC
  34. Wei J, Melichian D, Komura K, Hinchcliff M, Lam AP, Lafyatis R, Gottardi CJ, MacDougald OA, Varga J  Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?  Arthritis Rheum  2011 Jun;63(6):1707-17. doi:10.1002/art.30312
  35. Neumann S, Schneider M, Daugherty RL, Gottardi CJ, Eming SA, Beijer A, Noegel AA, Karakesisoglou I  Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.  J Biol Chem  2010 Nov 5;285(45):34932-8. doi:10.1074/jbc.M110.119651
  36. Maher MT, Mo R, Flozak AS, Peled ON, Gottardi CJ  Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling.  PLoS One  2010;5(4):e10184. doi:10.1371/journal.pone.0010184
  37. Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Mutlu GM, Budinger GR, Gottardi CJ  Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.  J Biol Chem  2010 Jan 29;285(5):3157-67. doi:10.1074/jbc.M109.070326
  38. Mo R, Chew TL, Maher MT, Bellipanni G, Weinberg ES, Gottardi CJ  The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.  J Biol Chem  2009 Oct 9;284(41):28222-31. doi:10.1074/jbc.M109.045039
  39. Verheyen EM, Gottardi CJ  Regulation of Wnt/beta-catenin signaling by protein kinases.  Dev Dyn  2010 Jan;239(1):34-44. doi:10.1002/dvdy.22019
  40. Maher MT, Flozak AS, Stocker AM, Chenn A, Gottardi CJ  Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion.  J Cell Biol  2009 Jul 27;186(2):219-28. doi:10.1083/jcb.200811108
  41. Maher MT, Flozak AS, Hartsell AM, Russell S, Beri R, Peled ON, Gottardi CJ  Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7.  Biol Direct  2009;4:5. doi:10.1186/1745-6150-4-5
  42. Jeanes A, Gottardi CJ, Yap AS  Cadherins and cancer: how does cadherin dysfunction promote tumor progression?  Oncogene  2008 Nov 24;27(55):6920-9. doi:10.1038/onc.2008.343
  43. Lal M, Song X, Pluznick JL, Di Giovanni V, Merrick DM, Rosenblum ND, Chauvet V, Gottardi CJ, Pei Y, Caplan MJ  Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling.  Hum Mol Genet  2008 Oct 15;17(20):3105-17. doi:10.1093/hmg/ddn208
  44. Padovan C, Bonfigli F, Ulessi B, Gottardi C, Giansante C, Trevisan G  Calciphylaxis of the breast: a rare disease in the differential diagnosis of breast cancer.  Acta Dermatovenerol Croat  2008;16(2):83-6
  45. Gottardi CJ, Peifer M  Terminal regions of beta-catenin come into view.  Structure  2008 Mar;16(3):336-8. doi:10.1016/j.str.2008.02.005
  46. Guo M, Breslin JW, Wu MH, Gottardi CJ, Yuan SY  VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability.  Am J Physiol Cell Physiol  2008 Apr;294(4):C977-84. doi:10.1152/ajpcell.90607.2007
  47. Niessen CM, Gottardi CJ  Molecular components of the adherens junction.  Biochim Biophys Acta  2008 Mar;1778(3):562-71. doi:10.1016/j.bbamem.2007.12.015
  48. Daugherty RL, Gottardi CJ  Phospho-regulation of Beta-catenin adhesion and signaling functions.  Physiology (Bethesda)  2007 Oct;22:303-9