Our lab is interested in several basic questions:
1) How are functions of microtubule motors regulated by accessory proteins?
2) How do microtubule motors organize cytoskeleton and establish cell polarity?
3) How do multiple motors of several types work together to move organelles?
4) How are intermediate filaments transported in cells, and what other cytoskeletal elements are necessary for their motility?
To answer these questions we use cultured cell lines (Drosophila S2 cells and mammalian cells) and cultures of primary neurons.