WHAT WE DO
The research in the Contractor lab is focused on investigation of the molecular mechanisms involved in modulating synaptic efficacy in the CNS. Synapses are the sites of contact between neurons and chemical transmission at these structures is central to all cognitive processes. In particular we have a strong interest in elucidating the molecular nature of synaptic plasticity of excitatory synapses, which is at the root of learning, memory and cognition.
We employ an array of technical approaches including single cell recording in brain slices, molecular analysis, cellular imaging and mouse behavior. Utilizing broad based technical approaches allows us to address fundamental questions about the basis of neurological dysfunction in disorders such as autism, fragile X, obsessive compulsive disorders and anxiety.
Modulation of neuronal excitability
Postsynaptic signaling by glutamate receptor complexes
Mechanisms of modulation of neurotransmitter release
Disruption of synaptic function in neurodevelopmental disorders
Fragile X Syndrome
Striatal circuit dysfunction in perseverative behaviors and affective disorders
303 E Chicago Ave
Chicago, IL 60611
LAB MEMBER LOGIN
Anis Contractor Lab
Website by S. Kraniotis | 2017