Northwestern University Feinberg School of Medicine

Nicholas Cianciotto Lab

Publications

Learn more about the work that we do in the Nicholas Cianciotto Laboratory through our recent publications.
  1. Truchan HK, Christman HD, White RC, Rutledge NS, Cianciotto NP  Type II Secretion Substrates of Legionella pneumophila Translocate Out of the Pathogen-Occupied Vacuole via a Semipermeable Membrane.  MBio  2017 Jun 20;8(3). pii:e00870-17
  2. Cianciotto NP, White RC  Expanding Role of Type II Secretion in Bacterial Pathogenesis and Beyond.  Infect Immun  2017 May;85(5). pii:e00014-17
  3. Mallama CA, McCoy-Simandle K, Cianciotto NP  The Type II Secretion System of Legionella pneumophila Dampens the MyD88 and Toll-Like Receptor 2 Signaling Pathway in Infected Human Macrophages.  Infect Immun  2017 Apr;85(4). pii:e00897-16
  4. White RC, Cianciotto NP  Type II Secretion Is Necessary for Optimal Association of the Legionella-Containing Vacuole with Macrophage Rab1B but Enhances Intracellular Replication Mainly by Rab1B-Independent Mechanisms.  Infect Immun  2016 Dec;84(12):3313-3327
  5. O'Connor TJ, Zheng H, VanRheenen SM, Ghosh S, Cianciotto NP, Isberg RR  Iron Limitation Triggers Early Egress by the Intracellular Bacterial Pathogen Legionella pneumophila.  Infect Immun  2016 Aug;84(8):2185-97. doi:10.1128/IAI.01306-15
  6. Aubi O, Flydal MI, Zheng H, Skjærven L, Rekand I, Leiros HK, Haug BE, Cianciotto NP, Martinez A, Underhaug J  Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila.  J Med Chem  2015 Nov 12;58(21):8402-12. doi:10.1021/acs.jmedchem.5b01589
  7. Burnside DM, Wu Y, Shafaie S, Cianciotto NP  The Legionella pneumophila Siderophore Legiobactin Is a Polycarboxylate That Is Identical in Structure to Rhizoferrin.  Infect Immun  2015 Oct;83(10):3937-45. doi:10.1128/IAI.00808-15
  8. DuMont AL, Karaba SM, Cianciotto NP  Type II Secretion-Dependent Degradative and Cytotoxic Activities Mediated by Stenotrophomonas maltophilia Serine Proteases StmPr1 and StmPr2.  Infect Immun  2015 Oct;83(10):3825-37. doi:10.1128/IAI.00672-15
  9. Cianciotto NP  An update on iron acquisition by Legionella pneumophila: new pathways for siderophore uptake and ferric iron reduction.  Future Microbiol  2015;10(5):841-51. doi:10.2217/fmb.15.21
  10. Gunderson FF, Mallama CA, Fairbairn SG, Cianciotto NP  Nuclease activity of Legionella pneumophila Cas2 promotes intracellular infection of amoebal host cells.  Infect Immun  2015 Mar;83(3):1008-18. doi:10.1128/IAI.03102-14
  11. Tyson JY, Vargas P, Cianciotto NP  The novel Legionella pneumophila type II secretion substrate NttC contributes to infection of amoebae Hartmannella vermiformis and Willaertia magna.  Microbiology  2014 Dec;160(Pt 12):2732-44. doi:10.1099/mic.0.082750-0
  12. Portier E, Zheng H, Sahr T, Burnside DM, Mallama C, Buchrieser C, Cianciotto NP, Héchard Y  IroT/mavN, a new iron-regulated gene involved in Legionella pneumophila virulence against amoebae and macrophages.  Environ Microbiol  2015 Apr;17(4):1338-50. doi:10.1111/1462-2920.12604
  13. Zheng H, Chatfield CH, Liles MR, Cianciotto NP  Secreted pyomelanin of Legionella pneumophila promotes bacterial iron uptake and growth under iron-limiting conditions.  Infect Immun  2013 Nov;81(11):4182-91. doi:10.1128/IAI.00858-13
  14. Cianciotto NP  Type II secretion and Legionella virulence.  Curr Top Microbiol Immunol  2013;376:81-102. doi:10.1007/82_2013_339
  15. Karaba SM, White RC, Cianciotto NP  Stenotrophomonas maltophilia encodes a type II protein secretion system that promotes detrimental effects on lung epithelial cells.  Infect Immun  2013 Sep;81(9):3210-9. doi:10.1128/IAI.00546-13
  16. Chaudhuri S, Gantner BN, Ye RD, Cianciotto NP, Freitag NE  The Listeria monocytogenes ChiA chitinase enhances virulence through suppression of host innate immunity.  MBio  2013 Mar 19;4(2):e00617-12. doi:10.1128/mBio.00617-12
  17. Gunderson FF, Cianciotto NP  The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae.  MBio  2013 Mar 12;4(2):e00074-13. doi:10.1128/mBio.00074-13
  18. Tyson JY, Pearce MM, Vargas P, Bagchi S, Mulhern BJ, Cianciotto NP  Multiple Legionella pneumophila Type II secretion substrates, including a novel protein, contribute to differential infection of the amoebae Acanthamoeba castellanii, Hartmannella vermiformis, and Naegleria lovaniensis.  Infect Immun  2013 May;81(5):1399-410. doi:10.1128/IAI.00045-13
  19. Stewart CR, Muthye V, Cianciotto NP  Legionella pneumophila persists within biofilms formed by Klebsiella pneumoniae, Flavobacterium sp., and Pseudomonas fluorescens under dynamic flow conditions.  PLoS One  2012;7(11):e50560. doi:10.1371/journal.pone.0050560
  20. Chatfield CH, Cianciotto NP  Culturing, media, and handling of legionella.  Methods Mol Biol  2013;954:151-62. doi:10.1007/978-1-62703-161-5_7
  21. Flydal MI, Chatfield CH, Zheng H, Gunderson FF, Aubi O, Cianciotto NP, Martinez A  Phenylalanine hydroxylase from Legionella pneumophila is a thermostable enzyme with a major functional role in pyomelanin synthesis.  PLoS One  2012;7(9):e46209. doi:10.1371/journal.pone.0046209
  22. Pearce MM, Theodoropoulos N, Mandel MJ, Brown E, Reed KD, Cianciotto NP  Legionella cardiaca sp. nov., isolated from a case of native valve endocarditis in a human heart.  Int J Syst Evol Microbiol  2012 Dec;62(Pt 12):2946-54. doi:10.1099/ijs.0.039248-0
  23. Chatfield CH, Mulhern BJ, Viswanathan VK, Cianciotto NP  The major facilitator superfamily-type protein LbtC promotes the utilization of the legiobactin siderophore by Legionella pneumophila.  Microbiology  2012 Mar;158(Pt 3):721-35. doi:10.1099/mic.0.055533-0