About Our Lab
We study the molecular pathogenesis of Legionella pneumophila, the bacterial agent of Legionnaires' disease; molecular and cellular bases of intracellular infection of human macrophages by bacterial pathogens; identification and characterization of bacterial genes and gene products that promote virulence; analysis of bacterial iron acquisition, adherence to host cells, secretion of toxins and other virulence factors, and antibiotic resistance. Alongside studying Legionella pneumophila, we also study Stenotrophomonas maltophilia, an emerging agent of human infection.
Burnside DM, Wu Y, Shafaie S, Cianciotto NP. The Legionella pneumophila Siderophore Legiobactin Is a Polycarboxylate That Is Identical in Structure to Rhizoferrin.Infect Immun PubMed: 26195554
DuMont AL, Karaba SM, Cianciotto NP. Type II Secretion-Dependent Degradative and Cytotoxic Activities Mediated by Stenotrophomonas maltophilia Serine Proteases StmPr1 and StmPr2.Infect Immun PubMed:26169274
Cianciotto NP. An update on iron acquisition by Legionella pneumophila: new pathways for siderophore uptake and ferric iron reduction.Future Microbiol PubMed:26000653
Gunderson FF, Mallama CA, Fairbairn SG, Cianciotto NP. Nuclease activity of Legionella pneumophila Cas2 promotes intracellular infection of amoebal host cells.Infect Immun PubMed:25547789
Tyson JY, Vargas P, Cianciotto NP The novel Legionella pneumophila type II secretion substrate NttC contributes to infection of amoebae Hartmannella vermiformis and Willaertia magna.Microbiology PubMed:25253612
- Congratulations Dr. Denise Burnside on the successful completion of your thesis defense!