Meet the Carvill Lab team members. We welcome requests for information about our work and collaboration opportunities.
Gemma L. Carvill, PhD
Assistant Professor of Neurology and Pharmacology
View Northwestern University Feinberg School of Medicine faculty profile
Dr. Carvill is an Assistant Professor of Neurology and Pharmacology at Northwestern University Feinberg School of Medicine. Dr. Carvill began her adventure in genetics as a graduate student in South Africa. A few brief research stints in Europe during her graduate studies solidified her passion for using cutting-edge genomic techniques to determine the genetic causes of neurodevelopmental disorders, and led her to a postdoctoral position at The University of Washington. In the laboratory of Dr. Heather Mefford, Dr. Carvill used genomics techniques to identify several new genes for the pediatric epilepsies, including CHD2, SYNGAP1 and SLC6A1. With career development awards from the NIH and CURE (Citizens United in Research for Epilepsy), Dr. Carvill developed her independent research program focused on genetic and epigenetic mechanisms underlying epilepsy. At Northwestern, Dr. Carvill will be interfacing with the clinical teams to expand neurogenetics research and to facilitate better genetic diagnoses, identify new causes of epilepsy and study how seizures occur using stem cell models.
Jeffrey Calhoun, PhD
Jeff received a PhD in Cellular and Molecular Biology at the University of Michigan in 2013. His dissertation research in Dr. Lori Isom’s laboratory focused on studying sodium channel beta subunit proteins in neuronal axon outgrowth and in breast cancer cells. As a postdoctoral fellow in Dr. Jennifer Kearney’s laboratory, Jeff elucidated Cacna1g as an epilepsy modifier gene in multiple mouse models of epilepsy. He also performed protein expression and trafficking studies on ion channel variants identified in epilepsy patients. This collaborative project with clinical geneticists and electrophysiologists inspired Jeff to pursue epilepsy gene discovery research in Dr. Gemma Carvill’s laboratory. Outside of the laboratory, Jeff enjoys racquetball (when his knees cooperate) and attempting to reproduce recipes from the internet (with occasional success)
Kay-Marie Lamar, PhD
Kay-Marie graduated with a PhD in Human Genetics from the University of Chicago in 2014. She completed her thesis work in the lab of Dr. Elizabeth McNally, studying the mechanism of a genetic modifier of muscular dystrophy (LTBP4) using both cell culture and mouse models. Kay-Marie then went on to join the team of Dr. Ann Harris at Lurie Children’s Hospital and continued to study genetic modifiers. Her project involved determining the mechanism behind a modifier locus of cystic fibrosis disease severity identified through GWAS. In the Harris lab, Kay-Marie focused on epigenetic methods, and worked to delete potential regulatory elements in lung cancer cell lines using CRISPR/Cas9. Outside of the lab, Kay-Marie enjoys taking advantage of Chicago summers, going to concerts in Millennium park, walking along the lakeshore path, and going to neighborhood festivals. She is also a theater-goer, and frequents the Steppenwolf, Chopin, and Goodman theaters.
Aishwarya Ramamurthy, MSc
Research Technologist II
Aishwarya graduated from Purdue School of Science, IUPUI, with an MS degree, where her research work at Kusmeirczyk lab focused on biochemical characterization of putative proteasomal assembly intermediates. She then joined Dr. Steve Kron’s research team at University of Chicago, to investigate DNA repair mechanisms and their significance in cancer metabolism, primarily using CRISPR methods. Aishwarya previously worked in national research institutes in India where her varied research projects spanned from studying genetic mutations associated with Hirschsprung’s disease, to biochemically characterizing human small heat shock proteins (sHsps) and their interactions with copper, to studying in-vitro regeneration responses of mature neem (A. Indica) trees in attempts to analyze their genomes, transcriptomes and metabolomes. Currently, Aishwarya is using stem cell modelling and next generation sequencing approaches to understand the pathogenic mechanisms that underpin pediatric genetic epilepsies.
Megan MC Schultz, BS
Research Technologist II
MC obtained a bachelor's degree in Biology from Illinois Institute of Technology. After graduating from IIT, they moved to the laboratory of Dr. Ozdinler at Northwestern. In the Ozdinler lab they participated in many research projects including studying the effects of UCHL1 abolition in motor neurons and how the protein's absence contributes to the pathology observed in amyotrophic lateral sclerosis (ALS). This included characterizing novel protein interactions with UCHL1.MC is planning to purse a doctoral degree with particular interests in genetics and development. Specifically, MC hopes to examine DNA regulation as a mechanism determining cell fate and interrogate the regulatory changes that occur as organisms evolve. Here at the Carvill laboratory MC is excited to investigate the role of chromatin remodelers in epilepsy. When not at the bench, MC enjoys thinking about science's impact on society and as an agent for societal evolution.
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