Northwestern University Feinberg School of Medicine

Gemma Carvill Lab

Our Mission

The primary goal of our research is to use gene discovery and molecular biology approaches to identify new treatments for epilepsy. We aim to 1) identify the genetic causes of epilepsy, 2) use stem cell models to understand how genetic mutations can cause epilepsy, 3) develop and test new therapeutics for this condition. Our work is based on the promise of precision medicine where knowledge of an individual’s genetic makeup shapes a personalized approach to care and management of epilepsy.

Recent publications

 

Myers CT, Hollingsworth G, Muir AM, Schneider AL, Thuesmunn Z, Knupp A, King C, Lacroix A, Mehaffey MG, Berkovic SF, Carvill GL, Sadleir LG, Scheffer IE, Mefford HC  Parental Mosaicism in "De Novo" Epileptic Encephalopathies.  N Engl J Med  2018 04 26;378(17):1646-1648. doi:10.1056/NEJMc1714579

Chatron N, Møller RS, Champaigne NL, Schneider AL, Kuechler A, Labalme A, Simonet T, Baggett L, Bardel C, Kamsteeg EJ, Pfundt R, Romano C, Aronsson J, Alberti A, Vinci M, Miranda MJ, Lacroix A, Marjanovic D, des Portes V, Edery P, Wieczorek D, Gardella E, Scheffer IE, Mefford H, Sanlaville D, Carvill GL, Lesca G  The epilepsy phenotypic spectrum associated with a recurrent CUX2 variant.  Ann Neurol  2018 May;83(5):926-934. doi:10.1002/ana.25222

News

  • Check out our new paper on CUX2 pathogenic variants published in Annals of Neurlogy

 

 


  • Meet Najma and Kristy, new undergrads joining the Carvill lab

Gemma L Carvill, PhD

Gemma L Carvill, PhD
Assistant Professor
Ken and Ruth Davee Department of Neurology
Department of Pharmacology
Center for Genetic Medicine

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