The primary goal of our research is to use gene discovery and molecular biology approaches to identify new treatments for epilepsy. We aim to 1) identify the genetic causes of epilepsy, 2) use stem cell models to understand how genetic mutations can cause epilepsy, 3) develop and test new therapeutics for this condition. Our work is based on the promise of precision medicine where knowledge of an individual’s genetic makeup shapes a personalized approach to care and management of epilepsy.
Corbett MA, Bellows ST, Li M, Carroll R, Micallef S, Carvill GL, Myers CT, Howell KB, Maljevic S, Lerche H, Gazina EV, Mefford HC, Bahlo M, Berkovic SF, Petrou S, Scheffer IE, Gecz J Dominant KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy.Neurology 2016 Nov 08;87(19):1975-1984
Carvill GL, Mefford HC Next-Generation Sequencing in Intellectual Disability.J Pediatr Genet 2015 Sep;4(3):128-35. doi:10.1055/s-0035-1564439
- Carvill lab opens October 2016
- We are seeking enthusiastic team members to join the fight on epilepsy. See our research and career opportunities for more information.