Northwestern University Feinberg School of Medicine

Bruce Bochner Lab

Recent Publications

Learn more about the work that we do in the Bruce Bochner Laboratory through our recent publications.
  1. Bochner BS  Novel Therapies for Eosinophilic Disorders.  Immunol Allergy Clin North Am  2015 Aug;35(3):577-98. doi:10.1016/j.iac.2015.05.007
  2. Bochner BS, Schleimer RP  Out of the orphanage and into the clinic--therapeutic targeting of GATA3.  N Engl J Med  2015 May 21;372(21):2060-1. doi:10.1056/NEJMe1502660
  3. Bochner BS, Kiwamoto T, Katoh T, Zhu Z, Tiemeyer M  Reply: To PMID 25497369.  J Allergy Clin Immunol  2015 Jun;135(6):1662-3. doi:10.1016/j.jaci.2015.02.028
  4. Jia Y, Yu H, Fernandes SM, Wei Y, Gonzalez-Gil A, Motari MG, Vajn K, Stevens WW, Peters AT, Bochner BS, Kern RC, Schleimer RP, Schnaar RL  Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells.  J Allergy Clin Immunol  2015 Mar;135(3):799-810.e7. doi:10.1016/j.jaci.2015.01.004
  5. Lynch KL, Dhalla S, Chedid V, Ravich WJ, Stein EM, Montgomery EA, Bochner BS, Clarke JO  Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis.  Dis Esophagus  2015 Jan 27;. doi:10.1111/dote.12307
  6. Bochner BS, Zimmermann N  Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation.  J Allergy Clin Immunol  2015 Mar;135(3):598-608. doi:10.1016/j.jaci.2014.11.031
  7. Schneider C, Smith DF, Cummings RD, Boligan KF, Hamilton RG, Bochner BS, Miescher S, Simon HU, Pashov A, Vassilev T, von Gunten S  The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites.  Sci Transl Med  2015 Jan 7;7(269):269ra1. doi:10.1126/scitranslmed.3010524
  8. Kiwamoto T, Katoh T, Evans CM, Janssen WJ, Brummet ME, Hudson SA, Zhu Z, Tiemeyer M, Bochner BS  Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.  J Allergy Clin Immunol  2015 May;135(5):1329-40.e1-9. doi:10.1016/j.jaci.2014.10.027
  9. Mao H, Kano G, Hudson SA, Brummet M, Zimmermann N, Zhu Z, Bochner BS  Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.  PLoS One  2013;8(6):e68143. doi:10.1371/journal.pone.0068143
  10. Kiwamoto T, Brummet ME, Wu F, Motari MG, Smith DF, Schnaar RL, Zhu Z, Bochner BS  Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation.  J Allergy Clin Immunol  2014 Jan;133(1):240-7.e1-3. doi:10.1016/j.jaci.2013.05.018
  11. Kim YH, Park CS, Lim DH, Son BK, Kim JH, Ahn SH, Bochner BS, Na K, Jang TY  Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis.  Am J Rhinol Allergy  ;27(3):187-91. doi:10.2500/ajra.2013.27.3866
  12. Kano G, Almanan M, Bochner BS, Zimmermann N  Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation.  J Allergy Clin Immunol  2013 Aug;132(2):437-45. doi:10.1016/j.jaci.2013.03.024
  13. Cook ML, Brodsky RA, Hamilton R, Wood RA, Bochner BS  High-dose cyclophosphamide used to treat aplastic anemia in a patient with respiratory and food allergies has a prolonged effect on serum IgE levels.  J Allergy Clin Immunol  2013 Jul;132(1):237-9. doi:10.1016/j.jaci.2013.01.033
  14. Bochner BS, Rothenberg ME, Boyce JA, Finkelman F  Advances in mechanisms of allergy and clinical immunology in 2012.  J Allergy Clin Immunol  2013 Mar;131(3):661-7. doi:10.1016/j.jaci.2012.12.676
  15. Valent P, Klion AD, Rosenwasser LJ, Arock M, Bochner BS, Butterfield JH, Gotlib J, Haferlach T, Hellmann A, Horny HP, Leiferman KM, Metzgeroth G, Matsumoto K, Reiter A, Roufosse F, Rothenberg ME, Simon HU, Sotlar K, Vandenberghe P, Weller PF, Gleich GJ  ICON: Eosinophil Disorders.  World Allergy Organ J  2012 Dec;5(12):174-81. doi:10.1097/WOX.0b013e31827f4192
  16. Kiwamoto T, Katoh T, Tiemeyer M, Bochner BS  The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation.  Curr Opin Allergy Clin Immunol  2013 Feb;13(1):106-11. doi:10.1097/ACI.0b013e32835b594a
  17. Bochner BS, Book W, Busse WW, Butterfield J, Furuta GT, Gleich GJ, Klion AD, Lee JJ, Leiferman KM, Minnicozzi M, Moqbel R, Rothenberg ME, Schwartz LB, Simon HU, Wechsler ME, Weller PF  Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD).  J Allergy Clin Immunol  2012 Sep;130(3):587-96. doi:10.1016/j.jaci.2012.07.024
  18. Wechsler ME, Fulkerson PC, Bochner BS, Gauvreau GM, Gleich GJ, Henkel T, Kolbeck R, Mathur SK, Ortega H, Patel J, Prussin C, Renzi P, Rothenberg ME, Roufosse F, Simon D, Simon HU, Wardlaw A, Weller PF, Klion AD  Novel targeted therapies for eosinophilic disorders.  J Allergy Clin Immunol  2012 Sep;130(3):563-71. doi:10.1016/j.jaci.2012.07.027
  19. Kiwamoto T, Kawasaki N, Paulson JC, Bochner BS  Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions.  Pharmacol Ther  2012 Sep;135(3):327-36. doi:10.1016/j.pharmthera.2012.06.005
  20. Na HJ, Hamilton RG, Klion AD, Bochner BS  Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8.  J Immunol Methods  2012 Sep 28;383(1-2):39-46. doi:10.1016/j.jim.2012.05.017
  21. Valent P, Gleich GJ, Reiter A, Roufosse F, Weller PF, Hellmann A, Metzgeroth G, Leiferman KM, Arock M, Sotlar K, Butterfield JH, Cerny-Reiterer S, Mayerhofer M, Vandenberghe P, Haferlach T, Bochner BS, Gotlib J, Horny HP, Simon HU, Klion AD  Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field.  Expert Rev Hematol  2012 Apr;5(2):157-76. doi:10.1586/ehm.11.81
  22. Valent P, Horny HP, Bochner BS, Haferlach T, Reiter A  Controversies and open questions in the definitions and classification of the hypereosinophilic syndromes and eosinophilic leukemias.  Semin Hematol  2012 Apr;49(2):171-81. doi:10.1053/j.seminhematol.2012.01.009
  23. Na HJ, Hudson SA, Bochner BS  IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils.  Cytokine  2012 Jan;57(1):169-74. doi:10.1016/j.cyto.2011.10.007
  24. Hudson SA, Herrmann H, Du J, Cox P, Haddad el-B, Butler B, Crocker PR, Ackerman SJ, Valent P, Bochner BS  Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression.  J Clin Immunol  2011 Dec;31(6):1045-53. doi:10.1007/s10875-011-9589-4
  25. Grader-Beck T, Boin F, von Gunten S, Smith D, Rosen A, Bochner BS  Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease.  Ann Rheum Dis  2011 Dec;70(12):2218-24. doi:10.1136/ard.2011.153130
  26. Park CS, Bochner BS  Potential targeting of siglecs, mast cell inhibitory receptors, in interstitial cystitis.  Int Neurourol J  2011 Jun;15(2):61-3. doi:10.5213/inj.2011.15.2.61
  27. North SJ, von Gunten S, Antonopoulos A, Trollope A, MacGlashan DW, Jang-Lee J, Dell A, Metcalfe DD, Kirshenbaum AS, Bochner BS, Haslam SM  Glycomic analysis of human mast cells, eosinophils and basophils.  Glycobiology  2012 Jan;22(1):12-22. doi:10.1093/glycob/cwr089
  28. Paterniti M, Kelly DC, Eckman JA, Sterba PM, Hamilton RG, Bochner BS, Macglashan DW, Saini SS  Cat allergen-induced blood basophil reactivity in vitro predicts acute human nasal allergen challenge responses in vivo.  Clin Exp Allergy  2011 Jul;41(7):963-9. doi:10.1111/j.1365-2222.2011.03719.x
  29. Broide DH, Finkelman F, Bochner BS, Rothenberg ME  Advances in mechanisms of asthma, allergy, and immunology in 2010.  J Allergy Clin Immunol  2011 Mar;127(3):689-95. doi:10.1016/j.jaci.2011.01.027
  30. Cook ML, Bochner BS  Update on biological therapeutics for asthma.  World Allergy Organ J  2010 Jun;3(6):188-94. doi:10.1097/WOX.0b013e3181e5ec5a
  31. Simon HU, Rothenberg ME, Bochner BS, Weller PF, Wardlaw AJ, Wechsler ME, Rosenwasser LJ, Roufosse F, Gleich GJ, Klion AD  Refining the definition of hypereosinophilic syndrome.  J Allergy Clin Immunol  2010 Jul;126(1):45-9. doi:10.1016/j.jaci.2010.03.042
  32. Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME  Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis.  J Allergy Clin Immunol  2010 Jul;126(1):160-5.e3. doi:10.1016/j.jaci.2010.04.037
  33. Bochner BS, Gleich GJ  What targeting eosinophils has taught us about their role in diseases.  J Allergy Clin Immunol  2010 Jul;126(1):16-25; quiz 26-7. doi:10.1016/j.jaci.2010.02.026
  34. Guo JP, Brummet ME, Myers AC, Na HJ, Rowland E, Schnaar RL, Zheng T, Zhu Z, Bochner BS  Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.  Am J Respir Cell Mol Biol  2011 Feb;44(2):238-43. doi:10.1165/rcmb.2010-0007OC
  35. Park YM, Bochner BS  Eosinophil survival and apoptosis in health and disease.  Allergy Asthma Immunol Res  2010 Apr;2(2):87-101. doi:10.4168/aair.2010.2.2.87
  36. Gao PS, Shimizu K, Grant AV, Rafaels N, Zhou LF, Hudson SA, Konno S, Zimmermann N, Araujo MI, Ponte EV, Cruz AA, Nishimura M, Su SN, Hizawa N, Beaty TH, Mathias RA, Rothenberg ME, Barnes KC, Bochner BS  Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.  Eur J Hum Genet  2010 Jun;18(6):713-9. doi:10.1038/ejhg.2009.239
  37. Eckman JA, Sterba PM, Kelly D, Alexander V, Liu MC, Bochner BS, Macglashan DW, Saini SS  Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge.  J Allergy Clin Immunol  2010 Apr;125(4):889-895.e7. doi:10.1016/j.jaci.2009.09.012
  38. Ogbogu PU, Bochner BS, Butterfield JH, Gleich GJ, Huss-Marp J, Kahn JE, Leiferman KM, Nutman TB, Pfab F, Ring J, Rothenberg ME, Roufosse F, Sajous MH, Sheikh J, Simon D, Simon HU, Stein ML, Wardlaw A, Weller PF, Klion AD  Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.  J Allergy Clin Immunol  2009 Dec;124(6):1319-25.e3. doi:10.1016/j.jaci.2009.09.022
  39. Hudson SA, Bovin NV, Schnaar RL, Crocker PR, Bochner BS  Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x.  J Pharmacol Exp Ther  2009 Aug;330(2):608-12. doi:10.1124/jpet.109.152439
  40. von Gunten S, Smith DF, Cummings RD, Riedel S, Miescher S, Schaub A, Hamilton RG, Bochner BS  Intravenous immunoglobulin contains a broad repertoire of anticarbohydrate antibodies that is not restricted to the IgG2 subclass.  J Allergy Clin Immunol  2009 Jun;123(6):1268-76.e15. doi:10.1016/j.jaci.2009.03.013
  41. Boyce JA, Broide D, Matsumoto K, Bochner BS  Advances in mechanisms of asthma, allergy, and immunology in 2008.  J Allergy Clin Immunol  2009 Mar;123(3):569-74. doi:10.1016/j.jaci.2009.01.041
  42. Bochner BS  Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.  Clin Exp Allergy  2009 Mar;39(3):317-24. doi:10.1111/j.1365-2222.2008.03173.x
  43. Liu Z, Lu X, Zhang XH, Bochner BS, Long XB, Zhang F, Wang H, Cui YH  Clara cell 10-kDa protein expression in chronic rhinosinusitis and its cytokine-driven regulation in sinonasal mucosa.  Allergy  2009 Jan;64(1):149-57. doi:10.1111/j.1398-9995.2008.01847.x
  44. von Gunten S, Bochner BS  Basic and clinical immunology of Siglecs.  Ann N Y Acad Sci  2008 Nov;1143:61-82. doi:10.1196/annals.1443.011
  45. Bochner BS, Alam R  Allergy and hypersensitivity.  Curr Opin Immunol  2008 Dec;20(6):682-3. doi:10.1016/j.coi.2008.10.001
  46. Zimmermann N, McBride ML, Yamada Y, Hudson SA, Jones C, Cromie KD, Crocker PR, Rothenberg ME, Bochner BS  Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils.  Allergy  2008 Sep;63(9):1156-63. doi:10.1111/j.1398-9995.2008.01709.x
  47. Nimrichter L, Burdick MM, Aoki K, Laroy W, Fierro MA, Hudson SA, Von Seggern CE, Cotter RJ, Bochner BS, Tiemeyer M, Konstantopoulos K, Schnaar RL  E-selectin receptors on human leukocytes.  Blood  2008 Nov 1;112(9):3744-52. doi:10.1182/blood-2008-04-149641
  48. Matsumoto K, Maeda A, Bochner BS, Wakiguchi H, Saito H  Induction of apoptosis in human basophils by anti-Fas antibody treatment in vitro.  Int Arch Allergy Immunol  2008;146 Suppl 1:40-6. doi:10.1159/000126060
  49. Conner E, Bochner BS, Brummet M, Beck LA  The effect of etanercept on the human cutaneous allergic response.  J Allergy Clin Immunol  2008 Jan;121(1):258-60. doi:10.1016/j.jaci.2007.10.044
  50. Simons FE, Frew AJ, Ansotegui IJ, Bochner BS, Golden DB, Finkelman FD, Leung DY, Lotvall J, Marone G, Metcalfe DD, Müller U, Rosenwasser LJ, Sampson HA, Schwartz LB, van Hage M, Walls AF  Practical allergy (PRACTALL) report: risk assessment in anaphylaxis.  Allergy  2008 Jan;63(1):35-7