Our Program

The Bochner lab is interested in the role of eosinophils, mast cells and basophils in human diseases.  The main focus of the lab is on the function of the pro-apoptotic and inhibitory receptor Siglec-8 on human eosinophils, basophils and mast cells, which we co-discovered in the late 1990’s, and their natural sialoside ligands.  We also study similar aspects of its closest counterpart in the mouse, namely Siglec-F.  We are exploring mechanisms, including intracellular signaling pathways, by which Siglec-8 engagement induces eosinophil apoptosis and inhibits mast cell mediator release.

Overall, our lab’s efforts center on translational immunology, cellular and molecular biology and glycobiology as we seek to define new paradigms for the treatment of eosinophil, mast cell and basophil-associated diseases including asthma.

Bruce S. Bochner, MD

Bruce S. Bochner, MD
Samuel M. Feinberg Professor of Medicine
Division of Allergy-Immunology, Department of Medicine