Meet the Lab team members. We welcome requests for information about our work and collaboration opportunities.
Geoffrey Swanson, PhD
Professor in Pharmacology
PhD: University of California-Los Angeles, Pharmacology (1993).
Cellular Electrophysiology; Drug Discovery; Epilepsy; Nervous System Diseases; Neurobiology; Neuroscience; Pain; Pharmacology
View Northwestern University Feinberg School of Medicine faculty profile
Dr. William Nobis, MD, PhD
MD: Vanderbilt University (2011). PhD: Vanderbilt University, Neuroscience (2009).
My interest is in elucidating mechanisms of epileptogenesis. Many cases of temporal lobe epilepsy are refractory to medical treatment, highlighting the need for further study in order to develop novel treatments. Both human pathology and various animal models of temporal lobe epilepsy are marked by hippocampal dentate granule cell hyperexcitability and extensive loss of dentate hilar mossy cells. I am interested in the network formed between hippocampal granule neurons and hilar mossy cells in epileptic states. I also maintain an interest in the role of psychological factors - namely stress and anxiety - in epilepsy and seizures.
Yomayra Guzman, PhD
PhD: Northwestern University, Neuroscience (2013). BA: Universidad de Puerto Rico, Biology (2007).
I want to understand how sugars and sugar-binding proteins affect neuronal function, synaptic plasticity and behavior. Galectins, a family of a β-galactoside binding proteins, have been associated with various neuropathologies. My research goal is to understand the role of these lectins on CNS function. Thus, I am currently working on characterizing the expression profile of galectin 8 in the CNS and PNS. In addition, I am studying the effects of these lectins in long-term potentiation of SC-CA1 hippocampal synapses. On a related project, I examine the role of the carbohydrate epitope HNK-1 in the central nervous system. Specifically, I study the neuroanatomical and receptor subtype specificity of this epitope and how it relates to synaptic plasticity in the CNS.
Tristan Hedrick, PhD
PhD: Northwestern University, Neuroscience (2013). BA: Amherst College, Biology (2005).
I study the effect of galectins on neuronal function in the CNS. Galectins are a family of β-galactoside binding proteins expressed throughout the periphery and the CNS. These proteins are generally studied regarding their role in cancer pathology, immune function, or cell-matrix interactions. My work examines the role of galectins in healthy brain function as well as their potential role in network hyperexcitability surrounding brain tumors. In a second project, I study the recurrent networks within the hilus that generate and sustain pathological network activity in temporal lobe epilepsy. I am particularly interested in the recurrent network formed between hippocampal granule neurons and hilar mossy cells- large, multipolar cells which make broad connections within the hilus and even between hemispheres and that are particularly prone to degeneration in epilepsy.
BA: Scripps College, Foreign Languages (2007).
Visiting Pre-Doctoral Fellow
MS: Toho University, Biology (2005).
(312) 503-0477 / (312) 503-0465
BA: Loyola University Chicago, Psychology (2014).