What We Do
We study the molecular and physiological properties of receptor proteins that underlie excitatory synaptic transmission in the mammalian brain. Current research focuses primarily on understanding the roles of kainate receptors, a family of glutamate receptors whose diverse physiological functions include modulation of neurotransmission and induction of synaptic plasticity. We are also interested in exploring how kainate receptors might contribute to pathological processes such as epilepsy and pain. The laboratory investigates kainate receptor function using a diverse group of techniques that include patch-clamp electrophysiology, selective pharmacological compounds, molecular and cellular techniques, and gene-targeted mice.
Geoff gave two talks entitled 'Kainate receptor signaling and its role in human neurological disorders' at the University of Kyoto and Hokkaido University (February 23 and March 4, 2018).
Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy published in The Journal of Experimental Medicine. (February 27, 2018)
Erica and Kendall presented posters at the Brain Research Foundation's 18th Annual Neuroscience Day. (February 16th, 2018)
Tristan left the Swanson Lab to teach at Lake Forest College - we will miss you! (December 2017)
Excitatory Synaptic Input to Hilar Mossy Cells under Basal and Hyperexcitable Conditions published in eNeuro. (November 22, 2017)
Kendall Foote (Timmons) joined the Swanson Lab as a graduate student. (November 2017)
Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy
Xu D, Robinson AP, Ishii T, Duncan DS, Alden TD, Goings GE, Ifergan I, Podojil JR, Penaloza-MacMaster P, Kearney JA, Swanson GT, Miller SD, Koh S.
The Journal of Experimental Medicine. (February 2018)
Excitatory synaptic input to hilar mossy cells under basal and hyperexcitable conditions
Hedrick TP, Nobis WP, Foote KM, Ishii T, Chetkovich DM, Swanson GT.
eNeuro. (November 2017)
Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation
Govind AP, Vallejo YF, Stolz JR, Yan JZ, Swanson GT, Green WN.
eLife. (July 2017)
N-glycan content modulates kainate receptor functional properties
Vernon CG, Copits BA, Stolz JR, Guzmán YF, Swanson GT.
The Journal of Physiology. (July 2017)